1-Cyclohexene-1-carboxylic acid, 6-hydroxy-4-methyl-, (4R,6S)- (9CI)

Base Information

• Chemical Name: 1-Cyclohexene-1-carboxylic acid, 6-hydroxy-4-methyl-, (4R,6S)- (9CI)
• CAS No.: 894415-72-6
• Molecular Formula: C8H12 O3
• Molecular Weight: 156.17908
• Mol file: 894415-72-6.mol

Synonyms:1-Cyclohexene-1-carboxylic acid, 6-hydroxy-4-methyl-, (4R,6S)- (9CI)

Chemical Property of 1-Cyclohexene-1-carboxylic acid, 6-hydroxy-4-methyl-, (4R,6S)- (9CI)

Chemical Property:

• PSA: 57.53000
• LogP: 0.78820

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Cyclohexene-1-carboxylic acid, 6-hydroxy-4-methyl-, (4R,6S)- (9CI)

There total 1 articles about 1-Cyclohexene-1-carboxylic acid, 6-hydroxy-4-methyl-, (4R,6S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4R,6S)-6-hydroxy-4-methyl-cyclohex-1-enecarbaldehyde (894415-66-8) → (4R,6S)-6-Hydroxy-4-methyl-cyclohex-1-enecarboxylic acid (894415-72-6)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 20 ℃; for 4h;

DOI:10.1021/ol060486+

Reference yield:

(4R,6S)-6-Hydroxy-4-methyl-cyclohex-1-enecarboxylic acid (894415-72-6) → 8-hydroxy-iso-menthol

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous HCl / 5 h / Heating

2: tetrahydrofuran; hexane / 2 h / 0 - 20 °C

3: hydrogen / Pd/C / ethyl acetate / 18 h / 20 °C / 760 Torr

With hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; hexane; ethyl acetate;

DOI:10.1021/ol060486+

Reference yield:

(4R,6S)-6-Hydroxy-4-methyl-cyclohex-1-enecarboxylic acid (894415-72-6) → (3S,5R)-2-(1-hydroxy-1-methylethyl)-5-methylcyclohexen-1-ol (212559-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous HCl / 5 h / Heating

2: tetrahydrofuran; hexane / 2 h / 0 - 20 °C

With hydrogenchloride; In tetrahydrofuran; hexane;

DOI:10.1021/ol060486+

upstream raw materials:

(4R,6S)-6-hydroxy-4-methyl-cyclohex-1-enecarbaldehyde

Downstream raw materials:

(4R,6S)-6-Hydroxy-4-methyl-cyclohex-1-enecarboxylic acid ethyl ester

(3S,5R)-2-(1-hydroxy-1-methylethyl)-5-methylcyclohexen-1-ol