1-(3-(4-methylpiperazin-1-yl)benzyl)-5-(5-(4-(trifluoromethoxy)phenyl)oxazol-2-yl)pyridin-2(1H)-one

Base Information

Chemical Name:1-(3-(4-methylpiperazin-1-yl)benzyl)-5-(5-(4-(trifluoromethoxy)phenyl)oxazol-2-yl)pyridin-2(1H)-one
CAS No.:1571024-77-5
Molecular Formula:C₂₇H₂₅F₃N₄O₃
Molecular Weight:510.516
Hs Code.:

Synonyms:1-(3-(4-methylpiperazin-1-yl)benzyl)-5-(5-(4-(trifluoromethoxy)phenyl)oxazol-2-yl)pyridin-2(1H)-one

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Chemical Property of 1-(3-(4-methylpiperazin-1-yl)benzyl)-5-(5-(4-(trifluoromethoxy)phenyl)oxazol-2-yl)pyridin-2(1H)-one

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Technology Process of 1-(3-(4-methylpiperazin-1-yl)benzyl)-5-(5-(4-(trifluoromethoxy)phenyl)oxazol-2-yl)pyridin-2(1H)-one

There total 7 articles about 1-(3-(4-methylpiperazin-1-yl)benzyl)-5-(5-(4-(trifluoromethoxy)phenyl)oxazol-2-yl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1571033-93-6
5-(5-(4-(trifluoromethoxy)phenyl)oxazol-2-yl)pyridin-2(1H)-one

: 1571033-98-1
1-(3-(chloromethyl)phenyl)-4-methylpiperazine

: 1571024-77-5
1-(3-(4-methylpiperazin-1-yl)benzyl)-5-(5-(4-(trifluoromethoxy)phenyl)oxazol-2-yl)pyridin-2(1H)-one

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1571024-77-5
1-(3-(4-methylpiperazin-1-yl)benzyl)-5-(5-(4-(trifluoromethoxy)phenyl)oxazol-2-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 20 °C

1.2: 1 h / 75 °C / Inert atmosphere

2.1: thionyl chloride / dichloromethane / 2 h / 60 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

With thionyl chloride; caesium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 2-amino-1-(4-(trifluoromethoxy)phenyl)ethanone

: 1571024-77-5
1-(3-(4-methylpiperazin-1-yl)benzyl)-5-(5-(4-(trifluoromethoxy)phenyl)oxazol-2-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1,1'-carbonyldiimidazole / dichloromethane / 8 h / 20 °C

2: sulfuric acid / 0.5 h / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

With sulfuric acid; caesium carbonate; 1,1'-carbonyldiimidazole; In dichloromethane; N,N-dimethyl-formamide;