4-benzyl-1-(3,5-dichlorophenyl)-2-[2-(trifluoromethyl)benzyl]-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one

Base Information

Chemical Name:4-benzyl-1-(3,5-dichlorophenyl)-2-[2-(trifluoromethyl)benzyl]-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one
CAS No.:1284151-82-1
Molecular Formula:C₃₀H₂₃Cl₂F₃N₂O
Molecular Weight:555.427
Hs Code.:

Synonyms:4-benzyl-1-(3,5-dichlorophenyl)-2-[2-(trifluoromethyl)benzyl]-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one

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Chemical Property of 4-benzyl-1-(3,5-dichlorophenyl)-2-[2-(trifluoromethyl)benzyl]-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one

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Technology Process of 4-benzyl-1-(3,5-dichlorophenyl)-2-[2-(trifluoromethyl)benzyl]-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one

There total 3 articles about 4-benzyl-1-(3,5-dichlorophenyl)-2-[2-(trifluoromethyl)benzyl]-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 392-83-6
o-trifluoromethylphenyl bromide

: 1284151-63-8
N-allyl-N-benzyl-2-(3,5-dichlorophenylamino)benzamide

: 1284151-82-1
4-benzyl-1-(3,5-dichlorophenyl)-2-[2-(trifluoromethyl)benzyl]-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; P(p-C₆H₄F)3; In 5,5-dimethyl-1,3-cyclohexadiene; at 135 ℃; Inert atmosphere;
DOI:10.1021/ol200429a

Reference yield:

: 18201-65-5
2-(3,5-dichlorophenylamino)benzoic acid

: 1284151-82-1
4-benzyl-1-(3,5-dichlorophenyl)-2-[2-(trifluoromethyl)benzyl]-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol / dichloromethane / 0.03 h / Inert atmosphere

1.2: 15 h / Inert atmosphere

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; P(p-C₆H₄F)3 / 5,5-dimethyl-1,3-cyclohexadiene / 135 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; benzotriazol-1-ol; sodium t-butanolate; P(p-C₆H₄F)3; In 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane;
DOI:10.1021/ol200429a

Reference yield:

: methyl 2-(3,5-dichlorophenylamino)benzoate

: 1284151-82-1
4-benzyl-1-(3,5-dichlorophenyl)-2-[2-(trifluoromethyl)benzyl]-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / ethanol; water / 3 h / Inert atmosphere; Reflux

1.2: pH 2 / Inert atmosphere

2.1: benzotriazol-1-ol / dichloromethane / 0.03 h / Inert atmosphere

2.2: 15 h / Inert atmosphere

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; P(p-C₆H₄F)3 / 5,5-dimethyl-1,3-cyclohexadiene / 135 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; benzotriazol-1-ol; potassium hydroxide; sodium t-butanolate; P(p-C₆H₄F)3; In 5,5-dimethyl-1,3-cyclohexadiene; ethanol; dichloromethane; water;
DOI:10.1021/ol200429a