[2-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-ethyl]-[2-(3,4-dimethoxy-phenyl)-ethyl]-amine

Base Information

Chemical Name:[2-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-ethyl]-[2-(3,4-dimethoxy-phenyl)-ethyl]-amine
CAS No.:212578-21-7
Molecular Formula:C₂₇H₃₂N₂O₃
Molecular Weight:432.563
Hs Code.:

Synonyms:[2-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-ethyl]-[2-(3,4-dimethoxy-phenyl)-ethyl]-amine

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Chemical Property of [2-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-ethyl]-[2-(3,4-dimethoxy-phenyl)-ethyl]-amine

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Technology Process of [2-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-ethyl]-[2-(3,4-dimethoxy-phenyl)-ethyl]-amine

There total 6 articles about [2-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-ethyl]-[2-(3,4-dimethoxy-phenyl)-ethyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 212578-54-6
2-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide

: 212578-21-7
[2-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-ethyl]-[2-(3,4-dimethoxy-phenyl)-ethyl]-amine

Guidance literature:: With dimethylsulfide borane complex; In tetrahydrofuran; for 4h; Heating;
DOI:10.1021/jm970795t

Reference yield:

: 1624-53-9,3230-45-3,137838-23-4
2-(benzylideneamino)phenol

: 212578-21-7
[2-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-ethyl]-[2-(3,4-dimethoxy-phenyl)-ethyl]-amine

Guidance literature:: Multi-step reaction with 6 steps

1: NaBH₄ / ethanol

2: NaHCO₃ / ethanol / 8 h / Ambient temperature

3: K₂CO₃ / ethanol / 1 h / Ambient temperature

4: 85 percent / KOH / ethanol / Ambient temperature

5: 68 percent / EDCI / CH₂Cl₂ / 5 h / Ambient temperature

6: 84 percent / BH₃*Me₂S / tetrahydrofuran / 4 h / Heating

With potassium hydroxide; sodium tetrahydroborate; dimethylsulfide borane complex; sodium hydrogencarbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm970795t

Reference yield:

: 77434-57-2
2-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)acetic acid

: 212578-21-7
[2-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-ethyl]-[2-(3,4-dimethoxy-phenyl)-ethyl]-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / EDCI / CH₂Cl₂ / 5 h / Ambient temperature

2: 84 percent / BH₃*Me₂S / tetrahydrofuran / 4 h / Heating

With dimethylsulfide borane complex; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm970795t