4-[1-(4-chloro-phenyl)-2-[1,2,4]triazol-1-yl-ethoxycarbonylmethyl]-5-oxo-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester

Base Information

• Chemical Name: 4-[1-(4-chloro-phenyl)-2-[1,2,4]triazol-1-yl-ethoxycarbonylmethyl]-5-oxo-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester
• CAS No.: 157469-27-7
• Molecular Formula: C₁₈H₁₆Cl₄N₄O₆
• Molecular Weight: 526.16
• Mol file: 157469-27-7.mol

Synonyms:4-[1-(4-chloro-phenyl)-2-[1,2,4]triazol-1-yl-ethoxycarbonylmethyl]-5-oxo-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester

Chemical Property of 4-[1-(4-chloro-phenyl)-2-[1,2,4]triazol-1-yl-ethoxycarbonylmethyl]-5-oxo-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[1-(4-chloro-phenyl)-2-[1,2,4]triazol-1-yl-ethoxycarbonylmethyl]-5-oxo-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester

There total 2 articles about 4-[1-(4-chloro-phenyl)-2-[1,2,4]triazol-1-yl-ethoxycarbonylmethyl]-5-oxo-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-p-chlorophenyl-2-(1,2,4-triazol-1-yl)ethanol (62881-59-8) + 4-chlorocarbonylmethyl-5-oxo-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester → 4-[1-(4-chloro-phenyl)-2-[1,2,4]triazol-1-yl-ethoxycarbonylmethyl]-5-oxo-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester (157469-27-7)

Guidance literature:

With pyridine; In tetrachloromethane; at 40 ℃; for 3h;

DOI:10.1002/ps.2780410403

Reference yield:

4-carboxymethyl-5-oxo-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester → 4-[1-(4-chloro-phenyl)-2-[1,2,4]triazol-1-yl-ethoxycarbonylmethyl]-5-oxo-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester (157469-27-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / SOCl₂ / CCl₄ / Heating

2: 85 percent / pyridine / CCl₄ / 3 h / 40 °C

With pyridine; thionyl chloride; In tetrachloromethane; 1: Substitution / 2: Substitution;

DOI:10.1002/ps.2780410403

Reference yield: 70.0%

4-[1-(4-chloro-phenyl)-2-[1,2,4]triazol-1-yl-ethoxycarbonylmethyl]-5-oxo-oxazolidine-3-carboxylic acid 2,2,2-trichloro-ethyl ester (157469-27-7) → 2-amino-succinic acid 4-[1-(4-chloro-phenyl)-2-[1,2,4]triazol-1-yl-ethyl] ester

Guidance literature:

With acetic acid; zinc; for 0.0833333h;

DOI:10.1002/ps.2780410403

upstream raw materials:

1-p-chlorophenyl-2-(1,2,4-triazol-1-yl)ethanol