C₄₃H₅₄N₆O₄

Base Information

• Chemical Name: C₄₃H₅₄N₆O₄
• CAS No.: 1560643-76-6
• Molecular Formula: C₄₃H₅₄N₆O₄
• Molecular Weight: 718.94
• Mol file: 1560643-76-6.mol

Synonyms:C₄₃H₅₄N₆O₄

Chemical Property of C₄₃H₅₄N₆O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₄₃H₅₄N₆O₄

There total 17 articles about C₄₃H₅₄N₆O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(2S,4S)-tert-butyl 2-(5-iodo-1H-imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate (1313207-07-6) + C36H46BN3O4 (1560643-67-5) → C43H54N6O4 (1560643-76-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 90 ℃; for 4h; Inert atmosphere;

Reference yield:

N-tert-Butyloxycarbonyl-(2S,4S)-4-methylproline (364750-81-2,871727-77-4) → C43H54N6O4 (1560643-76-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: diborane / tetrahydrofuran / 2 h / 0 - 20 °C

2.1: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 2 h / 0 - 20 °C

3.1: ammonia / methanol / 1.5 h / 0 - 20 °C

3.2: 24 h / 0 - 20 °C

4.1: N-iodo-succinimide / dichloromethane / 2 h / 0 °C

5.1: water; sodium sulfite / ethanol / 30 h / 90 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 4 h / 90 °C / Inert atmosphere

With N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; ammonia; water; potassium carbonate; diborane; sodium sulfite; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water;

Reference yield:

C25H36BN3O4 (1307310-41-3) → C43H54N6O4 (1560643-76-6)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 3 h / 90 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 4 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

upstream raw materials:

N-tert-Butyloxycarbonyl-(2S,4S)-4-methylproline

(2-(2-(4-bromophenyl)-2-oxoethyl)) 1-(tert-butyl) (2S,4S)-4-methylpyrrolidine-1,2-dicarboxylate

C₁₉H₂₄BrN₃O₂

C₂₅H₃₆BN₃O₄

Downstream raw materials:

C₄₇H₆₀N₈O₆