4-(4-Benzenesulfonyl-1,1-dioxo-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-butyraldehyde

Base Information

Chemical Name:4-(4-Benzenesulfonyl-1,1-dioxo-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-butyraldehyde
CAS No.:205110-33-4
Molecular Formula:C₁₄H₁₆O₅S₂
Molecular Weight:328.41
Hs Code.:

4-(4-Benzenesulfonyl-1,1-dioxo-2,5-dihydro-1H-1λ<sup>6</sup>-thiophen-2-yl)-butyraldehyde

Synonyms:4-(4-Benzenesulfonyl-1,1-dioxo-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-butyraldehyde

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Chemical Property of 4-(4-Benzenesulfonyl-1,1-dioxo-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-butyraldehyde

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Technology Process of 4-(4-Benzenesulfonyl-1,1-dioxo-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-butyraldehyde

There total 4 articles about 4-(4-Benzenesulfonyl-1,1-dioxo-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-butyraldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 205110-29-8
4-(4-Benzenesulfonyl-1,1-dioxo-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-butan-1-ol

: 205110-33-4
4-(4-Benzenesulfonyl-1,1-dioxo-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-butyraldehyde

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; Ambient temperature;
DOI:10.1016/S0040-4039(97)01037-X

Reference yield:

: 64741-13-5
3-thiophenyl-3-sulfolene

: 205110-33-4
4-(4-Benzenesulfonyl-1,1-dioxo-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-butyraldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) BuLi / 1.) HMPA, THF, -105 deg C, 2.) HMPA, THF, from -90 deg C to -50 deg C

2: 1.) 9-BBN, 2.) 3 N NaOH, 30 percent aq. H₂O₂ / 1.) THF, RT, 3 h, 2.) THF, RT, 1 h

3: 93 percent / MCPBA / CH₂Cl₂ / 1 h / 0 °C

4: 81 percent / PCC / CH₂Cl₂ / 2 h / Ambient temperature

With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; dihydrogen peroxide; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; In dichloromethane;
DOI:10.1002/jccs.199800028

Reference yield:

: 197862-44-5
4-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-butan-1-ol

: 205110-33-4
4-(4-Benzenesulfonyl-1,1-dioxo-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-butyraldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / MCPBA / CH₂Cl₂ / 1 h / 0 °C

2: 81 percent / PCC / CH₂Cl₂ / 2 h / Ambient temperature

With 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; In dichloromethane;
DOI:10.1002/jccs.199800028