methyl 3-<4-<1-(4-chlorophenyl)-2-oxo-pyrrolidin-4-yl>methyloxyphenyl>propionate

Base Information

Chemical Name:methyl 3-<4-<1-(4-chlorophenyl)-2-oxo-pyrrolidin-4-yl>methyloxyphenyl>propionate
CAS No.:133748-52-4
Molecular Formula:C₂₁H₂₂ClNO₄
Molecular Weight:387.863
Hs Code.:

Synonyms:methyl 3-<4-<1-(4-chlorophenyl)-2-oxo-pyrrolidin-4-yl>methyloxyphenyl>propionate

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Chemical Property of methyl 3-<4-<1-(4-chlorophenyl)-2-oxo-pyrrolidin-4-yl>methyloxyphenyl>propionate

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Technology Process of methyl 3-<4-<1-(4-chlorophenyl)-2-oxo-pyrrolidin-4-yl>methyloxyphenyl>propionate

There total 8 articles about methyl 3-<4-<1-(4-chlorophenyl)-2-oxo-pyrrolidin-4-yl>methyloxyphenyl>propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: methyl 4-<1-(4-chlorophenyl)-2-oxo-pyrrolidin-4-yl>methyloxycinnamate

: 133748-52-4
methyl 3-<4-<1-(4-chlorophenyl)-2-oxo-pyrrolidin-4-yl>methyloxyphenyl>propionate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 12h; under 760 Torr; Ambient temperature;
DOI:10.1016/0223-5234(94)90029-9

Reference yield:

: 97-65-4,25119-64-6
2-methylenesuccinic acid

: 133748-52-4
methyl 3-<4-<1-(4-chlorophenyl)-2-oxo-pyrrolidin-4-yl>methyloxyphenyl>propionate

Guidance literature:: Multi-step reaction with 6 steps

1: 93.5 percent / Heating

2: 92.6 percent / conc. H₂SO₄ / CH₂Cl₂ / Heating

3: 99 percent / NaBH₄, MeOH / tetrahydrofuran / Heating

4: Et₃N / CH₂Cl₂

5: 85.6 percent / K₂CO₃ / dimethylformamide / 80 °C

6: 83 percent / H₂ / 10percent Pd/C / ethyl acetate / 12 h / 760 Torr / Ambient temperature

With methanol; sodium tetrahydroborate; sulfuric acid; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(94)90029-9

Reference yield:

: 39629-87-3
1-(4-chlorophenyl)-5-oxo-3-pyrrolidinecarboxylic acid

: 133748-52-4
methyl 3-<4-<1-(4-chlorophenyl)-2-oxo-pyrrolidin-4-yl>methyloxyphenyl>propionate

Guidance literature:: Multi-step reaction with 5 steps

1: 92.6 percent / conc. H₂SO₄ / CH₂Cl₂ / Heating

2: 99 percent / NaBH₄, MeOH / tetrahydrofuran / Heating

3: Et₃N / CH₂Cl₂

4: 85.6 percent / K₂CO₃ / dimethylformamide / 80 °C

5: 83 percent / H₂ / 10percent Pd/C / ethyl acetate / 12 h / 760 Torr / Ambient temperature

With methanol; sodium tetrahydroborate; sulfuric acid; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(94)90029-9