(S)-4-[(S)-3-{(R)-2-Benzyloxycarbonylamino-2-[(2,4,5-trichloro-phenoxycarbonylmethyl)-carbamoyl]-ethylsulfanylcarbonyl}-1-((S)-1,2-dicarbamoyl-ethylcarbamoyl)-propylcarbamoyl]-4-tert-butoxycarbonylamino-butyric acid benzyl ester

Base Information

Chemical Name:(S)-4-[(S)-3-{(R)-2-Benzyloxycarbonylamino-2-[(2,4,5-trichloro-phenoxycarbonylmethyl)-carbamoyl]-ethylsulfanylcarbonyl}-1-((S)-1,2-dicarbamoyl-ethylcarbamoyl)-propylcarbamoyl]-4-tert-butoxycarbonylamino-butyric acid benzyl ester
CAS No.:80682-10-6
Molecular Formula:C₄₅H₅₂Cl₃N₇O₁₄S
Molecular Weight:1053.37
Hs Code.:

(S)-4-[(S)-3-{(R)-2-Benzyloxycarbonylamino-2-[(2,4,5-trichloro-phenoxycarbonylmethyl)-carbamoyl]-ethylsulfanylcarbonyl}-1-((S)-1,2-dicarbamoyl-ethylcarbamoyl)-propylcarbamoyl]-4-tert-butoxycarbonylamino-butyric acid benzyl ester

Synonyms:(S)-4-[(S)-3-{(R)-2-Benzyloxycarbonylamino-2-[(2,4,5-trichloro-phenoxycarbonylmethyl)-carbamoyl]-ethylsulfanylcarbonyl}-1-((S)-1,2-dicarbamoyl-ethylcarbamoyl)-propylcarbamoyl]-4-tert-butoxycarbonylamino-butyric acid benzyl ester

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Chemical Property of (S)-4-[(S)-3-{(R)-2-Benzyloxycarbonylamino-2-[(2,4,5-trichloro-phenoxycarbonylmethyl)-carbamoyl]-ethylsulfanylcarbonyl}-1-((S)-1,2-dicarbamoyl-ethylcarbamoyl)-propylcarbamoyl]-4-tert-butoxycarbonylamino-butyric acid benzyl ester

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Technology Process of (S)-4-[(S)-3-{(R)-2-Benzyloxycarbonylamino-2-[(2,4,5-trichloro-phenoxycarbonylmethyl)-carbamoyl]-ethylsulfanylcarbonyl}-1-((S)-1,2-dicarbamoyl-ethylcarbamoyl)-propylcarbamoyl]-4-tert-butoxycarbonylamino-butyric acid benzyl ester

There total 9 articles about (S)-4-[(S)-3-{(R)-2-Benzyloxycarbonylamino-2-[(2,4,5-trichloro-phenoxycarbonylmethyl)-carbamoyl]-ethylsulfanylcarbonyl}-1-((S)-1,2-dicarbamoyl-ethylcarbamoyl)-propylcarbamoyl]-4-tert-butoxycarbonylamino-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13574-13-5
Boc-Glu(OBzl)-OH

: 80682-10-6
(S)-4-[(S)-3-{(R)-2-Benzyloxycarbonylamino-2-[(2,4,5-trichloro-phenoxycarbonylmethyl)-carbamoyl]-ethylsulfanylcarbonyl}-1-((S)-1,2-dicarbamoyl-ethylcarbamoyl)-propylcarbamoyl]-4-tert-butoxycarbonylamino-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 0.5 h; 25 deg C

2: 96 percent / hydrogen, formic acid / Pd black / methanol / 0.25 h

3: CF₃CO₂H / CH₂Cl₂ / 0.5 h / 25 °C

4: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 0.5 h; 25 deg C

5: N,N'-dicyclohexylcarbodiimide / dimethylformamide / 1.) 0 deg C, 1 h, 2.) 25 deg C, 18 h

6: triethylamine / dimethylformamide / 4 h / 40 °C

7: N,N'-dicyclohexylcarbodiimide / dimethylformamide / 1.) 0 deg C, 1 h, 2.) 25 deg C, 18 h

With 4-methyl-morpholine; formic acid; hydrogen; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; isobutyl chloroformate; palladium; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00414a075

Reference yield:

: 80682-04-8
[N-α-Boc-O-γ-(benzyl)glutamyl]asparagyl-NH2

: 80682-10-6
(S)-4-[(S)-3-{(R)-2-Benzyloxycarbonylamino-2-[(2,4,5-trichloro-phenoxycarbonylmethyl)-carbamoyl]-ethylsulfanylcarbonyl}-1-((S)-1,2-dicarbamoyl-ethylcarbamoyl)-propylcarbamoyl]-4-tert-butoxycarbonylamino-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / hydrogen, formic acid / Pd black / methanol / 0.25 h

2: CF₃CO₂H / CH₂Cl₂ / 0.5 h / 25 °C

3: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) THF, -15 deg C, 5 min, 2.) -15 deg C, 0.5 h; 25 deg C

4: N,N'-dicyclohexylcarbodiimide / dimethylformamide / 1.) 0 deg C, 1 h, 2.) 25 deg C, 18 h

5: triethylamine / dimethylformamide / 4 h / 40 °C

6: N,N'-dicyclohexylcarbodiimide / dimethylformamide / 1.) 0 deg C, 1 h, 2.) 25 deg C, 18 h

With 4-methyl-morpholine; formic acid; hydrogen; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; isobutyl chloroformate; palladium; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00414a075

Reference yield:

: 6968-11-2
N,N'-bis(benzyloxycarbonyl)-L-cystine

: 80682-10-6
(S)-4-[(S)-3-{(R)-2-Benzyloxycarbonylamino-2-[(2,4,5-trichloro-phenoxycarbonylmethyl)-carbamoyl]-ethylsulfanylcarbonyl}-1-((S)-1,2-dicarbamoyl-ethylcarbamoyl)-propylcarbamoyl]-4-tert-butoxycarbonylamino-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

2: triethylamine / dimethylformamide / 4 h / 40 °C

3: N,N'-dicyclohexylcarbodiimide / dimethylformamide / 1.) 0 deg C, 1 h, 2.) 25 deg C, 18 h

With triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/ja00414a075