5-amino-1-cyclohexyl-6-(2-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

Base Information

Chemical Name:5-amino-1-cyclohexyl-6-(2-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
CAS No.:1363156-86-8
Molecular Formula:C₂₀H₂₀N₄O
Molecular Weight:332.405
Hs Code.:

Synonyms:5-amino-1-cyclohexyl-6-(2-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

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Chemical Property of 5-amino-1-cyclohexyl-6-(2-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

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Technology Process of 5-amino-1-cyclohexyl-6-(2-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

There total 4 articles about 5-amino-1-cyclohexyl-6-(2-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1363156-67-5
1-cyclohexyl-6-(2-hydroxyphenyl)-5-nitro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

: 1363156-86-8
5-amino-1-cyclohexyl-6-(2-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 48h; under 760.051 Torr;
DOI:10.1016/j.tet.2011.06.101

Reference yield:

: 59507-92-5
3-nitro-4H-chromen-4-one

: 1363156-86-8
5-amino-1-cyclohexyl-6-(2-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 1 h / Reflux; Inert atmosphere

2: palladium on activated charcoal; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr

With palladium on activated charcoal; hydrogen; acetic acid; In methanol;
DOI:10.1016/j.tet.2011.06.101

Reference yield:

: 1076-38-6,92395-12-5
4-hydroxy[1]benzopyran-2-one

: 1363156-86-8
5-amino-1-cyclohexyl-6-(2-hydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: nitric acid; acetic acid; sodium nitrite / 0.25 h / 60 °C

2: water; sodium hydroxide / 3 h / 60 °C

3: sulfuric acid / 6 h / Reflux

4: acetic acid / 1 h / Reflux; Inert atmosphere

5: palladium on activated charcoal; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr

With sulfuric acid; palladium on activated charcoal; water; hydrogen; nitric acid; acetic acid; sodium hydroxide; sodium nitrite; In methanol;
DOI:10.1016/j.tet.2011.06.101