2-<2-<4-(3-ethylureido)-3-hydroxyphenyl>ethyl>-7-methylimidazo<1,2-a>pyridine

Base Information

• Chemical Name: 2-<2-<4-(3-ethylureido)-3-hydroxyphenyl>ethyl>-7-methylimidazo<1,2-a>pyridine
• CAS No.: 128616-41-1
• Molecular Formula: C₁₉H₂₂N₄O₂
• Molecular Weight: 338.409
• Mol file: 128616-41-1.mol

Synonyms:2-<2-<4-(3-ethylureido)-3-hydroxyphenyl>ethyl>-7-methylimidazo<1,2-a>pyridine

Chemical Property of 2-<2-<4-(3-ethylureido)-3-hydroxyphenyl>ethyl>-7-methylimidazo<1,2-a>pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-<2-<4-(3-ethylureido)-3-hydroxyphenyl>ethyl>-7-methylimidazo<1,2-a>pyridine

There total 5 articles about 2-<2-<4-(3-ethylureido)-3-hydroxyphenyl>ethyl>-7-methylimidazo<1,2-a>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-<2-(4-amino-3-hydroxyphenyl)ethyl>-7-methylimidazo<1,2-a>pyridine (128616-03-5) + ethyl isocyanate (109-90-0) → 2-<2-<4-(3-ethylureido)-3-hydroxyphenyl>ethyl>-7-methylimidazo<1,2-a>pyridine (128616-41-1)

Guidance literature:

In tetrahydrofuran; methanol; for 2.5h; Ambient temperature;

DOI:10.1248/cpb.40.1424

Reference yield:

2-Amino-4-methylpyridine (695-34-1) → 2-<2-<4-(3-ethylureido)-3-hydroxyphenyl>ethyl>-7-methylimidazo<1,2-a>pyridine (128616-41-1)

Guidance literature:

Multi-step reaction with 4 steps

1: acetonitrile / 5.5 h / Heating

2: K₂CO₃ / acetonitrile; H₂O / 2.5 h / Ambient temperature

3: 98 percent / H₂ / 10percent Pd-C / methanol; tetrahydrofuran / 760 Torr / Ambient temperature

4: 71 percent / methanol; tetrahydrofuran / 2.5 h / Ambient temperature

With hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; water; acetonitrile;

DOI:10.1248/cpb.40.1424

Reference yield:

2-<2-(3-benzyloxy-4-nitrophenyl)vinyl>-7-methylimidazo<1,2-a>pyridine (128615-99-6) → 2-<2-<4-(3-ethylureido)-3-hydroxyphenyl>ethyl>-7-methylimidazo<1,2-a>pyridine (128616-41-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / H₂ / 10percent Pd-C / methanol; tetrahydrofuran / 760 Torr / Ambient temperature

2: 71 percent / methanol; tetrahydrofuran / 2.5 h / Ambient temperature

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1248/cpb.40.1424

upstream raw materials:

2-<2-(4-amino-3-hydroxyphenyl)ethyl>-7-methylimidazo<1,2-a>pyridine

ethyl isocyanate

2-Amino-4-methylpyridine

2-<2-(3-benzyloxy-4-nitrophenyl)vinyl>-7-methylimidazo<1,2-a>pyridine