4-amino-6-((1-(1-(3,5-difluorophenyl)-2-naphthalenyl)ethyl)amino)-5-pyrimidinecarbonitrile

Base Information

Chemical Name:4-amino-6-((1-(1-(3,5-difluorophenyl)-2-naphthalenyl)ethyl)amino)-5-pyrimidinecarbonitrile
CAS No.:1374193-12-0
Molecular Formula:C₂₃H₁₇F₂N₅
Molecular Weight:401.418
Hs Code.:

Synonyms:4-amino-6-((1-(1-(3,5-difluorophenyl)-2-naphthalenyl)ethyl)amino)-5-pyrimidinecarbonitrile

Suppliers and Price of 4-amino-6-((1-(1-(3,5-difluorophenyl)-2-naphthalenyl)ethyl)amino)-5-pyrimidinecarbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-amino-6-((1-(1-(3,5-difluorophenyl)-2-naphthalenyl)ethyl)amino)-5-pyrimidinecarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-amino-6-((1-(1-(3,5-difluorophenyl)-2-naphthalenyl)ethyl)amino)-5-pyrimidinecarbonitrile

There total 5 articles about 4-amino-6-((1-(1-(3,5-difluorophenyl)-2-naphthalenyl)ethyl)amino)-5-pyrimidinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374193-03-9
1-(1-(3,5-difluorophenyl)naphthalen-2-yl)ethanamine

: 60025-09-4
4-amino-6-chloropyrimidine-5-carbonitrile

: 1374193-12-0
4-amino-6-((1-(1-(3,5-difluorophenyl)-2-naphthalenyl)ethyl)amino)-5-pyrimidinecarbonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 100 ℃; for 16h;

Reference yield:

: 3378-82-3
1-bromo-2-naphthaldehyde

: 1374193-12-0
4-amino-6-((1-(1-(3,5-difluorophenyl)-2-naphthalenyl)ethyl)amino)-5-pyrimidinecarbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / 75 °C

2: diethyl ether; tetrahydrofuran / 16 h / 20 °C / Cooling with acetone-dry ice

3: potassium phosphate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene / 20 h / 100 °C / Inert atmosphere

4: hydrogenchloride; water / tetrahydrofuran / 0.08 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / butan-1-ol / 16 h / 100 °C

With hydrogenchloride; titanium(IV) tetraethanolate; potassium phosphate; water; N-ethyl-N,N-diisopropylamine; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; diethyl ether; toluene; butan-1-ol;

Reference yield:

: 1374192-57-0
(E)-N-((1-bromonaphthalen-2-yl)methylene)-2-methylpropane-2-sulfinamide

: 1374193-12-0
4-amino-6-((1-(1-(3,5-difluorophenyl)-2-naphthalenyl)ethyl)amino)-5-pyrimidinecarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether; tetrahydrofuran / 16 h / 20 °C / Cooling with acetone-dry ice

2: potassium phosphate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene / 20 h / 100 °C / Inert atmosphere

3: hydrogenchloride; water / tetrahydrofuran / 0.08 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / butan-1-ol / 16 h / 100 °C

With hydrogenchloride; potassium phosphate; water; N-ethyl-N,N-diisopropylamine; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; diethyl ether; toluene; butan-1-ol;