4-(4-chlorophenyl)-2-hydrazinyl-6-(thiophen-2-yl)-4,5-dihydropyrimidine

Base Information

Chemical Name:4-(4-chlorophenyl)-2-hydrazinyl-6-(thiophen-2-yl)-4,5-dihydropyrimidine
CAS No.:1228870-91-4
Molecular Formula:C₁₄H₁₃ClN₄S
Molecular Weight:304.803
Hs Code.:

Synonyms:4-(4-chlorophenyl)-2-hydrazinyl-6-(thiophen-2-yl)-4,5-dihydropyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-chlorophenyl)-2-hydrazinyl-6-(thiophen-2-yl)-4,5-dihydropyrimidine

Chemical Property:

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Technology Process of 4-(4-chlorophenyl)-2-hydrazinyl-6-(thiophen-2-yl)-4,5-dihydropyrimidine

There total 5 articles about 4-(4-chlorophenyl)-2-hydrazinyl-6-(thiophen-2-yl)-4,5-dihydropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1228870-89-0
4-(4-chlorophenyl)-2-(ethylthio)-6-(thiophen-2-yl)-4,5-dihydropyrimidine

: 1228870-91-4
4-(4-chlorophenyl)-2-hydrazinyl-6-(thiophen-2-yl)-4,5-dihydropyrimidine

Guidance literature:: With hydrazine hydrate; In ethanol; for 4h; Reflux;
DOI:10.1007/s12272-010-0501-1

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1228870-91-4
4-(4-chlorophenyl)-2-hydrazinyl-6-(thiophen-2-yl)-4,5-dihydropyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; potassium hydroxide / ethanol / 0.5 h / 0 °C

1.2: 20 °C

2.1: sodium hydroxide / ethanol / 6 h / Reflux

3.1: potassium hydroxide / ethanol; water / 2 h / 60 °C

4.1: hydrazine hydrate / ethanol / 4 h / Reflux

With water; hydrazine hydrate; potassium hydroxide; sodium hydroxide; In ethanol; water;
DOI:10.1007/s12272-010-0501-1

Reference yield:

: 88-15-3,97511-16-5
2-Acetylthiophene

: 1228870-91-4
4-(4-chlorophenyl)-2-hydrazinyl-6-(thiophen-2-yl)-4,5-dihydropyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; potassium hydroxide / ethanol / 0.5 h / 0 °C

1.2: 20 °C

2.1: sodium hydroxide / ethanol / 6 h / Reflux

3.1: potassium hydroxide / ethanol; water / 2 h / 60 °C

4.1: hydrazine hydrate / ethanol / 4 h / Reflux

With water; hydrazine hydrate; potassium hydroxide; sodium hydroxide; In ethanol; water;
DOI:10.1007/s12272-010-0501-1