3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-1-(4-trifluoromethoxyphenyl)-5-(R)-(3-fluoro-phenyl)-1,5-dihydro-pyrrol-2-one

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Chemical Name:3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-1-(4-trifluoromethoxyphenyl)-5-(R)-(3-fluoro-phenyl)-1,5-dihydro-pyrrol-2-one
CAS No.:1192801-32-3
Molecular Formula:C₂₅H₁₉F₇N₄O₂
Molecular Weight:540.44
Hs Code.:

Synonyms:3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-1-(4-trifluoromethoxyphenyl)-5-(R)-(3-fluoro-phenyl)-1,5-dihydro-pyrrol-2-one

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Chemical Property of 3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-1-(4-trifluoromethoxyphenyl)-5-(R)-(3-fluoro-phenyl)-1,5-dihydro-pyrrol-2-one

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Technology Process of 3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-1-(4-trifluoromethoxyphenyl)-5-(R)-(3-fluoro-phenyl)-1,5-dihydro-pyrrol-2-one

There total 5 articles about 3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-1-(4-trifluoromethoxyphenyl)-5-(R)-(3-fluoro-phenyl)-1,5-dihydro-pyrrol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1192801-24-3
1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamine

: 1192801-20-9
(R)-5-(3-fluoro-phenyl)-1-(4-trifluoromethoxy-phenyl)-pyrrolidine-2,3-dione

: 1192801-32-3
3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-1-(4-trifluoromethoxyphenyl)-5-(R)-(3-fluoro-phenyl)-1,5-dihydro-pyrrol-2-one

Guidance literature:: With acetic acid; In tetrahydrofuran; Isopropyl acetate; toluene; at 55 ℃; for 24h;

Reference yield:

: 1192801-22-1
2-(2-trifluoromethyl-pyrimidin-4-yl)-propan-2-ol

: 1192801-32-3
3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-1-(4-trifluoromethoxyphenyl)-5-(R)-(3-fluoro-phenyl)-1,5-dihydro-pyrrol-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 0 - 10 °C

1.2: 1 h / 90 °C

2.1: hydrogenchloride; water / 29 h / 100 °C

3.1: acetic acid / tetrahydrofuran; Isopropyl acetate; toluene / 24 h / 55 °C

With hydrogenchloride; sulfuric acid; water; acetic acid; In tetrahydrofuran; Isopropyl acetate; toluene;

Reference yield:

: 1192801-23-2
N-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethyl]-acetamide

: 1192801-32-3
3-[1-methyl-1-(2-trifluoromethyl-pyrimidin-4-yl)-ethylamino]-1-(4-trifluoromethoxyphenyl)-5-(R)-(3-fluoro-phenyl)-1,5-dihydro-pyrrol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; water / 29 h / 100 °C

2: acetic acid / tetrahydrofuran; Isopropyl acetate; toluene / 24 h / 55 °C

With hydrogenchloride; water; acetic acid; In tetrahydrofuran; Isopropyl acetate; toluene;