(2R)-2-[[6-chloro-2-[[(2,3-difluorophenyl)methyl]thio]-4-pyrimidinyl]oxy]-propanoic acid ethyl ester

Base Information

• Chemical Name: (2R)-2-[[6-chloro-2-[[(2,3-difluorophenyl)methyl]thio]-4-pyrimidinyl]oxy]-propanoic acid ethyl ester
• CAS No.: 878385-07-0
• Molecular Formula: C₁₆H₁₅ClF₂N₂O₃S
• Molecular Weight: 388.823

Synonyms:(2R)-2-[[6-chloro-2-[[(2,3-difluorophenyl)methyl]thio]-4-pyrimidinyl]oxy]-propanoic acid ethyl ester

Chemical Property of (2R)-2-[[6-chloro-2-[[(2,3-difluorophenyl)methyl]thio]-4-pyrimidinyl]oxy]-propanoic acid ethyl ester

Chemical Property:

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Technology Process of (2R)-2-[[6-chloro-2-[[(2,3-difluorophenyl)methyl]thio]-4-pyrimidinyl]oxy]-propanoic acid ethyl ester

There total 1 articles about (2R)-2-[[6-chloro-2-[[(2,3-difluorophenyl)methyl]thio]-4-pyrimidinyl]oxy]-propanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (2R)-2-[[6-chloro-2-[[(2,3-difluorophenyl)methyl]thio]-4-pyrimidinyl]oxy]-propanoic acid ethyl ester (878385-07-0)

Guidance literature:

Reference yield:

(3R,5S)-3,5-dimethylpiperazine-1-sulfonamide (654074-62-1) + (2R)-2-[[6-chloro-2-[[(2,3-difluorophenyl)methyl]thio]-4-pyrimidinyl]oxy]-propanoic acid ethyl ester (878385-07-0) → ethyl (2R)-2-[(2-[(2,3-difluorobenzyl)thio]-6-{[((3R,5S)-3,5-dimethylpiperazine)sulfonyl]amino}pyrimidin-4-yl)oxy]propanoate

Guidance literature:

With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; at 100 ℃; for 0.5h; Microwave irradiation;

Reference yield:

(2R)-2-[[6-chloro-2-[[(2,3-difluorophenyl)methyl]thio]-4-pyrimidinyl]oxy]-propanoic acid ethyl ester (878385-07-0) + 4-ethyl-piperazine-1-sulfonic acid amide (4114-84-5) → ethyl (2R)-2-[(2-[(2,3-difluorobenzyl)thio]-6-{[(4-ethylpiperazin-1-yl)sulfonyl]amino}pyrimidin-4-yl)oxy]propanoate

Guidance literature:

With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; at 100 ℃; for 0.5h; Microwave irradiation;

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