2-(1,3-benzodioxol-5-ylethynyl)-3-(1,3-dioxan-2-yl)-6-methoxyphenyl acetate

Base Information

Chemical Name:2-(1,3-benzodioxol-5-ylethynyl)-3-(1,3-dioxan-2-yl)-6-methoxyphenyl acetate
CAS No.:1310802-17-5
Molecular Formula:C₂₂H₂₀O₇
Molecular Weight:396.397
Hs Code.:

Synonyms:2-(1,3-benzodioxol-5-ylethynyl)-3-(1,3-dioxan-2-yl)-6-methoxyphenyl acetate

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Chemical Property of 2-(1,3-benzodioxol-5-ylethynyl)-3-(1,3-dioxan-2-yl)-6-methoxyphenyl acetate

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Technology Process of 2-(1,3-benzodioxol-5-ylethynyl)-3-(1,3-dioxan-2-yl)-6-methoxyphenyl acetate

There total 6 articles about 2-(1,3-benzodioxol-5-ylethynyl)-3-(1,3-dioxan-2-yl)-6-methoxyphenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1310802-12-0
2-(1,3-benzodioxol-5-ylethynyl)-3-acetoxy-4-methoxybenzaldehyde

: 504-63-2
trimethyleneglycol

: 1310802-17-5
2-(1,3-benzodioxol-5-ylethynyl)-3-(1,3-dioxan-2-yl)-6-methoxyphenyl acetate

Guidance literature:: With chloro-trimethyl-silane; In dichloromethane; for 2h; Inert atmosphere; Reflux;
DOI:10.1021/ol201130h

Reference yield:

: 621-59-0
isovanillin

: 1310802-17-5
2-(1,3-benzodioxol-5-ylethynyl)-3-(1,3-dioxan-2-yl)-6-methoxyphenyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; Iodine monochloride / 1,4-dioxane / 144 h / 0 - 20 °C / Inert atmosphere; Darkness

2: pyridine / 16 h / 20 °C / Inert atmosphere; Darkness

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / ethyl acetate / 21 h / -20 - 20 °C / Inert atmosphere

4: chloro-trimethyl-silane / dichloromethane / 2 h / Inert atmosphere; Reflux

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; chloro-trimethyl-silane; Iodine monochloride; diisopropylamine; In 1,4-dioxane; dichloromethane; ethyl acetate; 3: Sonogashira coupling;
DOI:10.1021/ol201130h

Reference yield:

: 57134-53-9
3,4-methylenedioxyphenylethyne

: 1310802-17-5
2-(1,3-benzodioxol-5-ylethynyl)-3-(1,3-dioxan-2-yl)-6-methoxyphenyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / ethyl acetate / 21 h / -20 - 20 °C / Inert atmosphere

2: chloro-trimethyl-silane / dichloromethane / 2 h / Inert atmosphere; Reflux

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; chloro-trimethyl-silane; diisopropylamine; In dichloromethane; ethyl acetate; 1: Sonogashira coupling;
DOI:10.1021/ol201130h