C₄₄H₆₇BrO₁₃Si₂

Base Information

• Chemical Name: C₄₄H₆₇BrO₁₃Si₂
• CAS No.: 861114-09-2
• Molecular Formula: C₄₄H₆₇BrO₁₃Si₂
• Molecular Weight: 940.083
• Mol file: 861114-09-2.mol

Synonyms:C₄₄H₆₇BrO₁₃Si₂

Chemical Property of C₄₄H₆₇BrO₁₃Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₄H₆₇BrO₁₃Si₂

There total 16 articles about C₄₄H₆₇BrO₁₃Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

C28H48O10Si2 (861113-88-4) + (1S,4S,5R)-2-Methoxy-5-(4-methoxy-benzyloxy)-bicyclo[2.2.1]hept-2-ene (615249-05-3) → C44H67BrO13Si2 (861114-09-2)

Guidance literature:

(1S,4S,5R)-2-Methoxy-5-(4-methoxy-benzyloxy)-bicyclo[2.2.1]hept-2-ene; With bromine; potassium carbonate; N,N-dimethyl-aniline; In dichloromethane; at -78 ℃; for 0.166667h;

C₂₈H₄₈O₁₀Si₂; With potassium carbonate; N,N-dimethyl-aniline; In dichloromethane; at -78 - 0 ℃; for 3h;

DOI:10.1002/anie.200500217

Reference yield:

C37H60O13Si2 (861113-99-7) → C44H67BrO13Si2 (861114-09-2)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 98 percent / Et₃N; DMAP / CH₂Cl₂ / 8 h / 0 - 25 °C

2.1: H₂ / Pd(OH)2/C / methanol; H₂O / 2 h / 25 °C / pH 7

3.1: base

4.1: NaBH₄ / methanol / 0.5 h / 0 - 25 °C

5.1: Pb(OAc)4 / CH₂Cl₂ / 2 h / 0 - 25 °C

6.1: 70 percent / DBU / toluene / 4 h / Heating

7.1: SOCl₂; pyridine / 8 h / 0 - 25 °C

7.2: K₂CO₃; MeOH / 2 h / 25 °C

8.1: Br₂; N,N-dimethylaniline; K₂CO₃ / CH₂Cl₂ / 0.17 h / -78 °C

8.2: 76 percent / N,N-dimethylaniline; K₂CO₃ / CH₂Cl₂ / 3 h / -78 - 0 °C

With pyridine; lead(IV) acetate; dmap; sodium tetrahydroborate; thionyl chloride; hydrogen; bromine; potassium carbonate; N,N-dimethyl-aniline; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium dihydroxide; In methanol; dichloromethane; water; toluene;

DOI:10.1002/anie.200500217

Reference yield:

C37H58O12Si2 (861114-18-3) → C44H67BrO13Si2 (861114-09-2)

Guidance literature:

Multi-step reaction with 11 steps

1.1: 56 percent / KHMDS / toluene; tetrahydrofuran / 0.5 h / -78 °C

2.1: 95 percent / Et₃SiH; Pd(PPh₃)4; LiCl / dimethylformamide / 24 h / 55 °C

3.1: 96 percent / K₂OsO₄*2H₂O; (DHQD)2PHAL; MeSO₂NH₂ / K₃Fe(CN)6; K₂CO₃ / 2-methyl-propan-2-ol; H₂O / 2 h

4.1: 98 percent / Et₃N; DMAP / CH₂Cl₂ / 8 h / 0 - 25 °C

5.1: H₂ / Pd(OH)2/C / methanol; H₂O / 2 h / 25 °C / pH 7

6.1: base

7.1: NaBH₄ / methanol / 0.5 h / 0 - 25 °C

8.1: Pb(OAc)4 / CH₂Cl₂ / 2 h / 0 - 25 °C

9.1: 70 percent / DBU / toluene / 4 h / Heating

10.1: SOCl₂; pyridine / 8 h / 0 - 25 °C

10.2: K₂CO₃; MeOH / 2 h / 25 °C

11.1: Br₂; N,N-dimethylaniline; K₂CO₃ / CH₂Cl₂ / 0.17 h / -78 °C

11.2: 76 percent / N,N-dimethylaniline; K₂CO₃ / CH₂Cl₂ / 3 h / -78 - 0 °C

With pyridine; lead(IV) acetate; triethylsilane; dmap; sodium tetrahydroborate; potassium osmate(VI); tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; methanesulfonamide; hydrogen; bromine; potassium hexamethylsilazane; potassium carbonate; N,N-dimethyl-aniline; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; lithium chloride; palladium dihydroxide; potassium carbonate; potassium hexacyanoferrate(III); In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

DOI:10.1002/anie.200500217

upstream raw materials:

C₂₈H₄₈O₁₀Si₂

(1S,4S,5R)-2-Methoxy-5-(4-methoxy-benzyloxy)-bicyclo[2.2.1]hept-2-ene

C₃₀H₅₀O₁₁Si₂

C₃₀H₅₂O₁₂Si₂

Downstream raw materials:

C₃₁H₃₆O₁₁

C₃₅H₄₀O₁₃

C₃₄H₃₆O₁₃

C₃₄H₃₈O₁₃