((1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-(3-chloro-4-hydroxy-phenyl)-1-{(S)-2-cyano-1-[(R)-1-(3-fluoro-4-nitro-phenyl)-2-methoxy-ethylcarbamoyl]-ethylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:((1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-(3-chloro-4-hydroxy-phenyl)-1-{(S)-2-cyano-1-[(R)-1-(3-fluoro-4-nitro-phenyl)-2-methoxy-ethylcarbamoyl]-ethylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester
CAS No.:197777-96-1
Molecular Formula:C₃₃H₄₅ClFN₅O₉Si
Molecular Weight:738.285
Hs Code.:

((1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-(3-chloro-4-hydroxy-phenyl)-1-{(S)-2-cyano-1-[(R)-1-(3-fluoro-4-nitro-phenyl)-2-methoxy-ethylcarbamoyl]-ethylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester

Synonyms:((1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-(3-chloro-4-hydroxy-phenyl)-1-{(S)-2-cyano-1-[(R)-1-(3-fluoro-4-nitro-phenyl)-2-methoxy-ethylcarbamoyl]-ethylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester

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Chemical Property of ((1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-(3-chloro-4-hydroxy-phenyl)-1-{(S)-2-cyano-1-[(R)-1-(3-fluoro-4-nitro-phenyl)-2-methoxy-ethylcarbamoyl]-ethylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester

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Technology Process of ((1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-(3-chloro-4-hydroxy-phenyl)-1-{(S)-2-cyano-1-[(R)-1-(3-fluoro-4-nitro-phenyl)-2-methoxy-ethylcarbamoyl]-ethylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester

There total 21 articles about ((1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-(3-chloro-4-hydroxy-phenyl)-1-{(S)-2-cyano-1-[(R)-1-(3-fluoro-4-nitro-phenyl)-2-methoxy-ethylcarbamoyl]-ethylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 197778-00-0
(S)-2-Amino-3-cyano-N-[(R)-1-(3-fluoro-4-nitro-phenyl)-2-methoxy-ethyl]-propionamide

: 197777-88-1
(2R,3R)-2-tert-Butoxycarbonylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-(3-chloro-4-hydroxy-phenyl)-propionic acid

: 197777-96-1
((1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-(3-chloro-4-hydroxy-phenyl)-1-{(S)-2-cyano-1-[(R)-1-(3-fluoro-4-nitro-phenyl)-2-methoxy-ethylcarbamoyl]-ethylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; for 8h; Ambient temperature;
DOI:10.1016/S0040-4039(97)01749-8

Reference yield:

: 4-benzyloxy-3-chlorophenyl magnesium bromide

: 197777-96-1
((1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-(3-chloro-4-hydroxy-phenyl)-1-{(S)-2-cyano-1-[(R)-1-(3-fluoro-4-nitro-phenyl)-2-methoxy-ethylcarbamoyl]-ethylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 2.) pyridine / 1.) THF, 0 deg C, 1 h, 2.) CH₂Cl₂, RT, 2 h

2: 70 percent / TFA / H₂O; CH₂Cl₂ / 1 h / Ambient temperature

3: 54 percent / Jones reagent / acetone / 1 h / 0 °C

4: 94 percent / K₂CO₃ / methanol / 0.5 h / Ambient temperature

5: 88 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

6: 96 percent / H₂ / Pd/C / ethyl acetate / 3 h / Ambient temperature

7: 65 percent / EDC, HOBt / dimethylformamide / 8 h / Ambient temperature

With pyridine; 2,6-dimethylpyridine; jones reagent; hydrogen; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4039(97)01749-8

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 197777-96-1
((1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-2-(3-chloro-4-hydroxy-phenyl)-1-{(S)-2-cyano-1-[(R)-1-(3-fluoro-4-nitro-phenyl)-2-methoxy-ethylcarbamoyl]-ethylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

2: 96 percent / H₂ / Pd/C / ethyl acetate / 3 h / Ambient temperature

3: 65 percent / EDC, HOBt / dimethylformamide / 8 h / Ambient temperature

With 2,6-dimethylpyridine; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(97)01749-8