2,4-Dioxo-1-[4-(4-diphenylmethoxy-1-piperidinyl)butyl]-1,2,3,4-tetrahydroquinazoline

Base Information

• Chemical Name: 2,4-Dioxo-1-[4-(4-diphenylmethoxy-1-piperidinyl)butyl]-1,2,3,4-tetrahydroquinazoline
• CAS No.: 221534-24-3
• Molecular Formula: C₃₀H₃₃N₃O₃
• Molecular Weight: 483.61

Synonyms:2,4-Dioxo-1-[4-(4-diphenylmethoxy-1-piperidinyl)butyl]-1,2,3,4-tetrahydroquinazoline

Chemical Property of 2,4-Dioxo-1-[4-(4-diphenylmethoxy-1-piperidinyl)butyl]-1,2,3,4-tetrahydroquinazoline

Chemical Property:

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Technology Process of 2,4-Dioxo-1-[4-(4-diphenylmethoxy-1-piperidinyl)butyl]-1,2,3,4-tetrahydroquinazoline

There total 1 articles about 2,4-Dioxo-1-[4-(4-diphenylmethoxy-1-piperidinyl)butyl]-1,2,3,4-tetrahydroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-chlorobutyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline (142374-71-8) + 1-(4-bromobutyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline (221540-26-7) + 4-diphenylmethoxypiperidine (58258-01-8) → 2,4-Dioxo-1-[4-(4-diphenylmethoxy-1-piperidinyl)butyl]-1,2,3,4-tetrahydroquinazoline (221534-24-3)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide;

Reference yield: 100.0%

2,4-Dioxo-1-[4-(4-diphenylmethoxy-1-piperidinyl)butyl]-1,2,3,4-tetrahydroquinazoline (221534-24-3) → 2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline-3-valeric acid (221536-23-8)

Guidance literature:

Reference yield: 86.0%

2,4-Dioxo-1-[4-(4-diphenylmethoxy-1-piperidinyl)butyl]-1,2,3,4-tetrahydroquinazoline (221534-24-3) + 1-bromo-2-phenylpropane (1459-00-3) → 2,4-Dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-3-(3-phenylpropyl)-1,2,3,4-tetrahydroquinazoline hydrochloride (221536-18-1)

Guidance literature:

With sodium iodide; potassium carbonate; In water; N,N-dimethyl-formamide;

upstream raw materials:

1-(4-chlorobutyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline

1-(4-bromobutyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline

4-diphenylmethoxypiperidine

Downstream raw materials:

3-Benzyl-2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline hydrochloride

2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline-3-valeric acid

3-[(2-Methoxycarbonylphenyl)methyl]-2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline hydrochloride

3-[(4-Methoxycarbonylphenyl)methyl]-2,4-dioxo-1-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline hydrochloride

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