Technology Process of trans-N-tosyl-5-n-heptyl-(S)-2-iodomethylpyrrolidine
There total 8 articles about trans-N-tosyl-5-n-heptyl-(S)-2-iodomethylpyrrolidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
methyl magnesium iodide;
In
dichloromethane;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 83 percent / pyridine / 24 h / Heating
2: 84 percent / P2S5 / benzene / 0.75 h / Heating
3: CH3ONa / methanol / 0.75 h / 0 °C
4: 81 percent / CH2Cl2 / 72 h / Heating
5: 85 percent / diisobutylaluminium hydride / CH2Cl2; hexane / 1) -78 degC, 10 min; 2) room temp., overnight
6: 90 percent / 4-dimethylaminopyridine / CH2Cl2 / 12 h / Ambient temperature
7: 18 percent / 1) methylmagnesium iodide / CH2Cl2 / Ambient temperature
With
pyridine; dmap; methyl magnesium iodide; tetraphosphorus decasulfide; sodium methylate; diisobutylaluminium hydride;
In
methanol; hexane; dichloromethane; benzene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 81 percent / CH2Cl2 / 72 h / Heating
2: 85 percent / diisobutylaluminium hydride / CH2Cl2; hexane / 1) -78 degC, 10 min; 2) room temp., overnight
3: 90 percent / 4-dimethylaminopyridine / CH2Cl2 / 12 h / Ambient temperature
4: 18 percent / 1) methylmagnesium iodide / CH2Cl2 / Ambient temperature
With
dmap; methyl magnesium iodide; diisobutylaluminium hydride;
In
hexane; dichloromethane;
