(S)-tert-butyl 2-(4-(4-(6-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-methoxyquinoxalin-2-yl)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

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Chemical Name:(S)-tert-butyl 2-(4-(4-(6-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-methoxyquinoxalin-2-yl)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate
CAS No.:1261072-33-6
Molecular Formula:C₅₁H₇₄N₈O₇Si₂
Molecular Weight:967.369
Hs Code.:

(S)-tert-butyl 2-(4-(4-(6-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-methoxyquinoxalin-2-yl)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Synonyms:(S)-tert-butyl 2-(4-(4-(6-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-methoxyquinoxalin-2-yl)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

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Chemical Property of (S)-tert-butyl 2-(4-(4-(6-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-methoxyquinoxalin-2-yl)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

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Technology Process of (S)-tert-butyl 2-(4-(4-(6-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-methoxyquinoxalin-2-yl)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

There total 8 articles about (S)-tert-butyl 2-(4-(4-(6-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-methoxyquinoxalin-2-yl)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1179149-96-2
tert-butyl (2S)-2-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1261072-32-5
6-bromo-2-(4-bromophenyl)-3-methoxyquinoxaline

: 1261072-34-7
tert-butyl (2S)-2-(4-{4-[6-(2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-4-yl)-3-hydroxyquinoxalin-2-yl]phenyl}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1261072-33-6
(S)-tert-butyl 2-(4-(4-(6-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-methoxyquinoxalin-2-yl)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: With potassium carbonate; Trimethylacetic acid; palladium diacetate; tricyclohexylphosphine tetrafluoroborate; In ISOPROPYLAMIDE; at 140 ℃; for 16h;

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 1261072-33-6
(S)-tert-butyl 2-(4-(4-(6-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-methoxyquinoxalin-2-yl)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: aluminum (III) chloride / dichloromethane / 18 h / 0 - 20 °C

2.1: triethylamine; titanium tetrachloride / dichloromethane / 18 h / 0 - 20 °C

3.1: acetic acid; iron / 4 h / 70 °C

3.2: 2 h / Reflux

4.1: trichlorophosphate / 5 h / 100 °C

5.1: tetrahydrofuran; methanol / 24 h / 20 °C

6.1: potassium carbonate; Trimethylacetic acid / palladium diacetate; tricyclohexylphosphine tetrafluoroborate / ISOPROPYLAMIDE / 16 h / 140 °C

With aluminum (III) chloride; titanium tetrachloride; iron; potassium carbonate; acetic acid; triethylamine; trichlorophosphate; Trimethylacetic acid; palladium diacetate; tricyclohexylphosphine tetrafluoroborate; In tetrahydrofuran; methanol; dichloromethane; ISOPROPYLAMIDE;

Reference yield:

: 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol

: 1261072-33-6
(S)-tert-butyl 2-(4-(4-(6-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-methoxyquinoxalin-2-yl)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate; sodium hypochlorite; sodium bromide / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 1.5 h / 0 °C

1.2: 19 h / 20 °C / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere

2.2: 1.5 h / 20 °C

3.1: potassium carbonate; Trimethylacetic acid / palladium diacetate; tricyclohexylphosphine tetrafluoroborate / ISOPROPYLAMIDE / 16 h / 140 °C

With sodium hypochlorite; sodium hydride; sodium hydrogencarbonate; potassium carbonate; sodium bromide; Trimethylacetic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium diacetate; tricyclohexylphosphine tetrafluoroborate; In dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; mineral oil;