N-(5-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}pentyl)-L-leucine mono-trifluoroacetate

Base Information

Chemical Name:N-(5-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}pentyl)-L-leucine mono-trifluoroacetate
CAS No.:956932-17-5
Molecular Formula:C₂HF₃O₂*C₂₉H₃₁F₄N₃O₅
Molecular Weight:691.6
Hs Code.:

Synonyms:N-(5-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}pentyl)-L-leucine mono-trifluoroacetate

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Chemical Property of N-(5-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}pentyl)-L-leucine mono-trifluoroacetate

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Technology Process of N-(5-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}pentyl)-L-leucine mono-trifluoroacetate

There total 3 articles about N-(5-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}pentyl)-L-leucine mono-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: tert-butyl N-(5-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}pentyl)-L-leucinate

: 76-05-1
trifluoroacetic acid

: 956932-17-5
N-(5-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}pentyl)-L-leucine mono-trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 20h;

Reference yield:

: 602311-69-3
6-amino-5-(2,4-difluorobenzoyl)-1-(2,6-difluoro-4-hydroxy-phenyl)-1H-pyridin-2-one

: 956932-17-5
N-(5-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}pentyl)-L-leucine mono-trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; sodium iodide / acetone / 16 h / 70 °C

2: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 20 h / 90 °C

3: dichloromethane / 20 h / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 54512-75-3
1-bromo-5-chloropentane

: 956932-17-5
N-(5-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenoxy}pentyl)-L-leucine mono-trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; sodium iodide / acetone / 16 h / 70 °C

2: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 20 h / 90 °C

3: dichloromethane / 20 h / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; acetone;