N-4-benzyloxycarbonylaminobutyl-N,N'-di-tert-butoxycarbonylguanidine

Base Information

• Chemical Name: N-4-benzyloxycarbonylaminobutyl-N,N'-di-tert-butoxycarbonylguanidine
• CAS No.: 132502-56-8
• Molecular Formula: C₂₃H₃₆N₄O₆
• Molecular Weight: 464.562
• Mol file: 132502-56-8.mol

Synonyms:N-4-benzyloxycarbonylaminobutyl-N,N'-di-tert-butoxycarbonylguanidine

Chemical Property of N-4-benzyloxycarbonylaminobutyl-N,N'-di-tert-butoxycarbonylguanidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-4-benzyloxycarbonylaminobutyl-N,N'-di-tert-butoxycarbonylguanidine

There total 2 articles about N-4-benzyloxycarbonylaminobutyl-N,N'-di-tert-butoxycarbonylguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(4-aminobutyl)carbamic acid benzyl ester (62146-62-7) + N,N'-bis-Boc-S-methyl-isothiourea (322474-21-5) → N-4-benzyloxycarbonylaminobutyl-N,N'-di-tert-butoxycarbonylguanidine (132502-56-8)

Guidance literature:

In tetrahydrofuran; water; for 48h; Ambient temperature;

DOI:10.1021/jm981013e

Reference yield: 86.0%

(4-aminobutyl)carbamic acid benzyl ester (62146-62-7) + N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine (152120-54-2,862686-58-6,1143572-00-2) → N-4-benzyloxycarbonylaminobutyl-N,N'-di-tert-butoxycarbonylguanidine (132502-56-8)

Guidance literature:

With triethylamine; In water; acetonitrile;

DOI:10.1016/j.bmcl.2009.08.068

Reference yield:

N-4-benzyloxycarbonylaminobutyl-N,N'-di-tert-butoxycarbonylguanidine (132502-56-8) → C52H78N8O18

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium on activated charcoal / methanol / 6 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

With palladium on activated charcoal; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;

DOI:10.1021/ml5000096

upstream raw materials:

(4-aminobutyl)carbamic acid benzyl ester

N,N'-bis-Boc-S-methyl-isothiourea

N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine