methyl (2E)-3-(4-chlorophenyl)-2-[(prop-2-ynyloxy)methyl]acrylate

Base Information

• Chemical Name: methyl (2E)-3-(4-chlorophenyl)-2-[(prop-2-ynyloxy)methyl]acrylate
• CAS No.: 786682-49-3
• Molecular Formula: C₁₄H₁₃ClO₃
• Molecular Weight: 264.708
• Mol file: 786682-49-3.mol

Synonyms:methyl (2E)-3-(4-chlorophenyl)-2-[(prop-2-ynyloxy)methyl]acrylate

Chemical Property of methyl (2E)-3-(4-chlorophenyl)-2-[(prop-2-ynyloxy)methyl]acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2E)-3-(4-chlorophenyl)-2-[(prop-2-ynyloxy)methyl]acrylate

There total 2 articles about methyl (2E)-3-(4-chlorophenyl)-2-[(prop-2-ynyloxy)methyl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 2-[1-hydroxy-1-(4-chlorophenyl)methyl]acrylate (131469-67-5) + propargyl alcohol (107-19-7) → methyl (2E)-3-(4-chlorophenyl)-2-[(prop-2-ynyloxy)methyl]acrylate (786682-49-3)

Guidance literature:

Montmorillonite K₁₀; at 75 ℃; for 24h;

DOI:10.1016/j.tet.2004.07.067

Reference yield:

methyl 2-[1-hydroxy-1-(4-chlorophenyl)methyl]acrylate (131469-67-5) + propargyl alcohol (107-19-7) → methyl (2E)-3-(4-chlorophenyl)-2-[(prop-2-ynyloxy)methyl]acrylate (786682-49-3) + (Z)-methyl 3-(4-chlorophenyl)-2-((prop-2-ynyloxy)methyl)acrylate

Guidance literature:

With SiO₂Cl; at 100 ℃; for 12h;

DOI:10.1071/CH07123

Reference yield: 97.0%

methyl (2E)-3-(4-chlorophenyl)-2-[(prop-2-ynyloxy)methyl]acrylate (786682-49-3) → methyl 3-(4-chlorobenzyl)-4-methylenetetrahydrofuran-3-carboxylate (786682-65-3)

Guidance literature:

methyl (2E)-3-(4-chlorophenyl)-2-[(prop-2-ynyloxy)methyl]acrylate; With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; at 85 ℃;

With hydrogenchloride; In diethyl ether; at 20 ℃; for 2h;

DOI:10.1016/j.tet.2004.07.067

upstream raw materials:

methyl 2-[1-hydroxy-1-(4-chlorophenyl)methyl]acrylate

propargyl alcohol

Downstream raw materials:

methyl 3-(4-chlorobenzyl)-4-methylenetetrahydrofuran-3-carboxylate

3-(4-chloro-benzyl)-4-methylene-tetrahydro-furan-3-carboxylic acid