N-Isopropyl-6-(3-methyl-5-phenyl-3H-[1,2,3]triazol-4-ylmethoxy)-nicotinamide

Base Information

Chemical Name:N-Isopropyl-6-(3-methyl-5-phenyl-3H-[1,2,3]triazol-4-ylmethoxy)-nicotinamide
CAS No.:1374671-95-0
Molecular Formula:C₁₉H₂₁N₅O₂
Molecular Weight:351.408
Hs Code.:

Synonyms:N-Isopropyl-6-(3-methyl-5-phenyl-3H-[1,2,3]triazol-4-ylmethoxy)-nicotinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Isopropyl-6-(3-methyl-5-phenyl-3H-[1,2,3]triazol-4-ylmethoxy)-nicotinamide

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Technology Process of N-Isopropyl-6-(3-methyl-5-phenyl-3H-[1,2,3]triazol-4-ylmethoxy)-nicotinamide

There total 6 articles about N-Isopropyl-6-(3-methyl-5-phenyl-3H-[1,2,3]triazol-4-ylmethoxy)-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1374672-81-7
6-(3-methyl-5-phenyl-3H-[1,2,3]triazol-4-ylmethoxy)-nicotinic acid methyl ester

: 75-31-0
isopropylamine

: 1374671-95-0
N-Isopropyl-6-(3-methyl-5-phenyl-3H-[1,2,3]triazol-4-ylmethoxy)-nicotinamide

Guidance literature:: With trimethylaluminum; In 1,4-dioxane; n-heptane; at 20 - 90 ℃; for 6h;

Reference yield:

: 536-74-3
phenylacetylene

: 1374671-95-0
N-Isopropyl-6-(3-methyl-5-phenyl-3H-[1,2,3]triazol-4-ylmethoxy)-nicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium azide; ascorbic acid / copper(l) iodide / water / 6 h / 20 °C / Sonication

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.67 h / -75 °C / Inert atmosphere

2.2: 1 h / -75 - 20 °C

3.1: sodium tetrahydroborate / methanol / 1 h / 20 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran; mineral oil / 20.5 h / 0 - 20 °C

5.1: trimethylaluminum / n-heptane; 1,4-dioxane / 6 h / 20 - 90 °C

With ascorbic acid; sodium tetrahydroborate; n-butyllithium; sodium azide; trimethylaluminum; sodium hydride; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; n-heptane; water; mineral oil;

Reference yield:

: 1374672-80-6
(3-methyl-5-phenyl-3H-[1,2,3]triazol-4-yl)-methanol

: 1374671-95-0
N-Isopropyl-6-(3-methyl-5-phenyl-3H-[1,2,3]triazol-4-ylmethoxy)-nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 20.5 h / 0 - 20 °C

2: trimethylaluminum / n-heptane; 1,4-dioxane / 6 h / 20 - 90 °C

With trimethylaluminum; sodium hydride; In tetrahydrofuran; 1,4-dioxane; n-heptane; mineral oil;