({(1S,3R)-3-[(1Z)-but-1-en-3-ynyl]cyclohexyl}oxy)(tert-butyl)diphenyl silane

Base Information

Chemical Name:({(1S,3R)-3-[(1Z)-but-1-en-3-ynyl]cyclohexyl}oxy)(tert-butyl)diphenyl silane
CAS No.:521274-54-4
Molecular Formula:C₂₆H₃₂OSi
Molecular Weight:388.625
Hs Code.:

Synonyms:({(1S,3R)-3-[(1Z)-but-1-en-3-ynyl]cyclohexyl}oxy)(tert-butyl)diphenyl silane

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Chemical Property of ({(1S,3R)-3-[(1Z)-but-1-en-3-ynyl]cyclohexyl}oxy)(tert-butyl)diphenyl silane

Chemical Property:

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Technology Process of ({(1S,3R)-3-[(1Z)-but-1-en-3-ynyl]cyclohexyl}oxy)(tert-butyl)diphenyl silane

There total 7 articles about ({(1S,3R)-3-[(1Z)-but-1-en-3-ynyl]cyclohexyl}oxy)(tert-butyl)diphenyl silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 521274-52-2
tert-butyl (diphenyl)({(1S,3R)-3-[(1Z)-4-(trimethylsilyl)but-1-en-3-ynyl]cyclohexyl}oxy)silane

: 521274-54-4
({(1S,3R)-3-[(1Z)-but-1-en-3-ynyl]cyclohexyl}oxy)(tert-butyl)diphenyl silane

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 2h;
DOI:10.1021/ja0340679

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 521274-54-4
({(1S,3R)-3-[(1Z)-but-1-en-3-ynyl]cyclohexyl}oxy)(tert-butyl)diphenyl silane

Guidance literature:: Multi-step reaction with 6 steps

1.1: imidazole / dimethylformamide / 1 h / 20 °C

1.2: H₂ / 10 percent Pd/C / ethyl acetate / 12 h / 760 Torr

2.1: DCC; DMAP / toluene / 1 h / 20 °C

3.1: Et₃SiH / 10 percentPd/C / CH₂Cl₂ / 0.33 h / 20 °C

4.1: NaHMDS / tetrahydrofuran

4.2: HMPA / tetrahydrofuran / -78 - 20 °C

5.1: 76 percent / Et₃NH; CuI; PdCl₂(PPh₃)2 / 0.5 h / 0 °C

6.1: K₂CO₃ / methanol / 2 h / 20 °C

With 1H-imidazole; triethylsilane; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylammonium; sodium hexamethyldisilazane; potassium carbonate; dicyclohexyl-carbodiimide; 10% palladium on active carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja0340679

Reference yield:

: 521274-50-0
benzyl (1R,5R)-5-hydroxycyclohex-3-ene-1-carboxylate

: 521274-54-4
({(1S,3R)-3-[(1Z)-but-1-en-3-ynyl]cyclohexyl}oxy)(tert-butyl)diphenyl silane

Guidance literature:: Multi-step reaction with 6 steps

1.1: imidazole / dimethylformamide / 1 h / 20 °C

1.2: H₂ / 10 percent Pd/C / ethyl acetate / 12 h / 760 Torr

2.1: DCC; DMAP / toluene / 1 h / 20 °C

3.1: Et₃SiH / 10 percentPd/C / CH₂Cl₂ / 0.33 h / 20 °C

4.1: NaHMDS / tetrahydrofuran

4.2: HMPA / tetrahydrofuran / -78 - 20 °C

5.1: 76 percent / Et₃NH; CuI; PdCl₂(PPh₃)2 / 0.5 h / 0 °C

6.1: K₂CO₃ / methanol / 2 h / 20 °C

With 1H-imidazole; triethylsilane; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylammonium; sodium hexamethyldisilazane; potassium carbonate; dicyclohexyl-carbodiimide; 10% palladium on active carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja0340679