(4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylamine

Base Information

• Chemical Name: (4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylamine
• CAS No.: 418759-83-8
• Molecular Formula: C₃₂H₄₃NO₅Si
• Molecular Weight: 549.783

Synonyms:(4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylamine

Chemical Property of (4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylamine

There total 5 articles about (4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{(2R,3S)-5-Azido-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yloxy}-tert-butyl-dimethyl-silane (833480-25-4) → (4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylamine (418759-83-8)

Guidance literature:

With hydrogen; Lindlar's catalyst; In ethanol; for 1.25h; under 2327.17 Torr;

DOI:10.1021/jo048253o

Reference yield:

1,3,5-tri-O-acetyl-2-deoxyribose (4594-52-9,96291-74-6,96291-75-7) → (4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylamine (418759-83-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 85 percent / TMSN₃; TMSOTf / CH₂Cl₂

2: NaOMe; MeOH / 0.25 h

3: pyridine / 12 h / 4 °C

4: imidazole; pyridine / 25 °C

5: H₂ / Pd/CaCO₃ / ethanol / 2 h / 1034.32 Torr

With pyridine; 1H-imidazole; methanol; trimethylsilyl trifluoromethanesulfonate; trimethylsilylazide; hydrogen; sodium methylate; Lindlar's catalyst; In ethanol; dichloromethane;

DOI:10.1021/ja012135q

Reference yield:

3,5-di-O-acetyl-2-deoxy-D-ribofuranosyl azide (367518-84-1) → (4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylamine (418759-83-8)

Guidance literature:

Multi-step reaction with 4 steps

1: NaOMe; MeOH / 0.25 h

2: pyridine / 12 h / 4 °C

3: imidazole; pyridine / 25 °C

4: H₂ / Pd/CaCO₃ / ethanol / 2 h / 1034.32 Torr

With pyridine; 1H-imidazole; methanol; hydrogen; sodium methylate; Lindlar's catalyst; In ethanol;

DOI:10.1021/ja012135q

upstream raw materials:

{(2R,3S)-5-Azido-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yloxy}-tert-butyl-dimethyl-silane

1,3,5-tri-O-acetyl-2-deoxyribose

2-deoxy-α,β-D-erythropentofuranosyl azide

3,5-di-O-acetyl-2-deoxy-D-ribofuranosyl azide

Downstream raw materials:

C₆₀H₇₅N₈O₁₆PSi

C₅₉H₇₃N₈O₁₇PSi

C₅₉H₇₄N₇O₁₆PSi

C₅₉H₇₄N₇O₁₆PSi

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 418759-83-8 (4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-ylamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send