{1-[(2R,3R,4R,5R)-4-(Allyloxy-diisopropylamino-phosphanyloxy)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester

Base Information

• Chemical Name: {1-[(2R,3R,4R,5R)-4-(Allyloxy-diisopropylamino-phosphanyloxy)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester
• CAS No.: 361448-15-9
• Molecular Formula: C₄₉H₆₇N₄O₁₀PSi
• Molecular Weight: 931.151

Synonyms:{1-[(2R,3R,4R,5R)-4-(Allyloxy-diisopropylamino-phosphanyloxy)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester

Chemical Property of {1-[(2R,3R,4R,5R)-4-(Allyloxy-diisopropylamino-phosphanyloxy)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester

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Technology Process of {1-[(2R,3R,4R,5R)-4-(Allyloxy-diisopropylamino-phosphanyloxy)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester

There total 5 articles about {1-[(2R,3R,4R,5R)-4-(Allyloxy-diisopropylamino-phosphanyloxy)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(allyloxy)bis(diisopropylamino)phosphine (108554-72-9) + {1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester (205925-98-0) → {1-[(2R,3R,4R,5R)-4-(Allyloxy-diisopropylamino-phosphanyloxy)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester (361448-15-9)

Guidance literature:

With 1H-tetrazole; isopropylamine; In acetonitrile; at 25 ℃; for 6h;

DOI:10.1016/S0040-4039(98)00157-9

Reference yield:

N4-[(allyloxy)carbonyl]cytidine (115516-59-1) → {1-[(2R,3R,4R,5R)-4-(Allyloxy-diisopropylamino-phosphanyloxy)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester (361448-15-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 50 percent / pyridine / 25 °C

2: AgNO₃, pyridine / tetrahydrofuran / 25 °C

3: Et₃N / methanol

4: 60 percent / iPrNH₂, 1H-tetrazole / acetonitrile / 6 h / 25 °C

With pyridine; 1H-tetrazole; silver nitrate; isopropylamine; triethylamine; In tetrahydrofuran; methanol; acetonitrile;

DOI:10.1016/S0040-4039(98)00157-9

Reference yield:

(1-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid allyl ester (205925-97-9) → {1-[(2R,3R,4R,5R)-4-(Allyloxy-diisopropylamino-phosphanyloxy)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester (361448-15-9)

Guidance literature:

Multi-step reaction with 3 steps

1: AgNO₃, pyridine / tetrahydrofuran / 25 °C

2: Et₃N / methanol

3: 60 percent / iPrNH₂, 1H-tetrazole / acetonitrile / 6 h / 25 °C

With pyridine; 1H-tetrazole; silver nitrate; isopropylamine; triethylamine; In tetrahydrofuran; methanol; acetonitrile;

DOI:10.1016/S0040-4039(98)00157-9

upstream raw materials:

(allyloxy)bis(diisopropylamino)phosphine

{1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid allyl ester

N⁴-[(allyloxy)carbonyl]cytidine

(1-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid allyl ester

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