Technology Process of 5-(4-hydroxyphenyl)-6-methoxy-2-(3',4',5'-trimethoxybenzoyl)quinoline
There total 5 articles about 5-(4-hydroxyphenyl)-6-methoxy-2-(3',4',5'-trimethoxybenzoyl)quinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-bromo-6-methoxy-2-(3',4',5'-trimethoxybenzoyl)quinoline; (p-hydroxyphenyl)boronic acid;
With
potassium dichromate;
tetrakis(triphenylphosphine) palladium(0);
In
toluene;
at 180 ℃;
for 0.166667h;
Microwave irradiation;
Sealed flask;
With
sodium hydrogencarbonate;
In
water; ethyl acetate; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-Bromosuccinimide / acetonitrile / 6 h / 0 - 20 °C
1.3: 1 h / 20 °C / pH 9
2.1: selenium(IV) oxide / para-xylene / 5 h / 20 °C / Reflux
3.1: tetrahydrofuran / 48 h / 0 - 20 °C
3.2: 0 °C
4.1: dipyridinium dichromate / dichloromethane / 16 h / 20 °C / Molecular sieve
5.1: potassium dichromate / tetrakis(triphenylphosphine) palladium(0) / toluene / 0.17 h / 180 °C / Microwave irradiation; Sealed flask
With
potassium dichromate; selenium(IV) oxide; N-Bromosuccinimide; dipyridinium dichromate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; dichloromethane; para-xylene; toluene; acetonitrile;
3.1: Grignard Reaction;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: selenium(IV) oxide / para-xylene / 5 h / 20 °C / Reflux
2.1: tetrahydrofuran / 48 h / 0 - 20 °C
2.2: 0 °C
3.1: dipyridinium dichromate / dichloromethane / 16 h / 20 °C / Molecular sieve
4.1: potassium dichromate / tetrakis(triphenylphosphine) palladium(0) / toluene / 0.17 h / 180 °C / Microwave irradiation; Sealed flask
With
potassium dichromate; selenium(IV) oxide; dipyridinium dichromate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; dichloromethane; para-xylene; toluene;
2.1: Grignard Reaction;
