N-(tert-butoxycarbonyl)-N-{2-(1'S,4'R,6'S)-1'-[3,4-(methylenedioxy)phenyl]-4'-(tert-butyldimethylsilyloxy)-2'-cyclohexenyl}ethyl amine

Base Information

Chemical Name:N-(tert-butoxycarbonyl)-N-{2-(1'S,4'R,6'S)-1'-[3,4-(methylenedioxy)phenyl]-4'-(tert-butyldimethylsilyloxy)-2'-cyclohexenyl}ethyl amine
CAS No.:712280-97-2
Molecular Formula:C₂₆H₄₁NO₆Si
Molecular Weight:491.7
Hs Code.:

Synonyms:N-(tert-butoxycarbonyl)-N-{2-(1'S,4'R,6'S)-1'-[3,4-(methylenedioxy)phenyl]-4'-(tert-butyldimethylsilyloxy)-2'-cyclohexenyl}ethyl amine

Suppliers and Price of N-(tert-butoxycarbonyl)-N-{2-(1'S,4'R,6'S)-1'-[3,4-(methylenedioxy)phenyl]-4'-(tert-butyldimethylsilyloxy)-2'-cyclohexenyl}ethyl amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(tert-butoxycarbonyl)-N-{2-(1'S,4'R,6'S)-1'-[3,4-(methylenedioxy)phenyl]-4'-(tert-butyldimethylsilyloxy)-2'-cyclohexenyl}ethyl amine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(tert-butoxycarbonyl)-N-{2-(1'S,4'R,6'S)-1'-[3,4-(methylenedioxy)phenyl]-4'-(tert-butyldimethylsilyloxy)-2'-cyclohexenyl}ethyl amine

There total 9 articles about N-(tert-butoxycarbonyl)-N-{2-(1'S,4'R,6'S)-1'-[3,4-(methylenedioxy)phenyl]-4'-(tert-butyldimethylsilyloxy)-2'-cyclohexenyl}ethyl amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 712280-96-1
N-(tert-butoxycarbonyl)-N-{2-(1'S,4'R,6'S)-1'-[3,4-(methylenedioxy)phenyl]-6'-benzyloxy-4'-(tert-butyldimethylsilyloxy)-cyclohex-2'-enyl}ethyl-N-(p-toluenesulfonyl)-amine

: 712280-97-2
N-(tert-butoxycarbonyl)-N-{2-(1'S,4'R,6'S)-1'-[3,4-(methylenedioxy)phenyl]-4'-(tert-butyldimethylsilyloxy)-2'-cyclohexenyl}ethyl amine

Guidance literature:: With Na-naphthalene; In tetrahydrofuran; at -40 ℃; for 1.5h;
DOI:10.1039/b402762k

Reference yield:

: 17680-04-5
(3,4-methylenedioxy)phenylmagnesium bromide

: 712280-97-2
N-(tert-butoxycarbonyl)-N-{2-(1'S,4'R,6'S)-1'-[3,4-(methylenedioxy)phenyl]-4'-(tert-butyldimethylsilyloxy)-2'-cyclohexenyl}ethyl amine

Guidance literature:: Multi-step reaction with 7 steps

1: 91 percent / tetrahydrofuran / 1 h / -100 °C

2: pyridinium chlorochromate; molecular sieves 4 Angstroem / CH₂Cl₂ / 0.5 h / 20 °C

3: 1.87 g / CeCl₃*7H₂O; NaBH₄ / methanol; CH₂Cl₂ / 0.5 h / -78 °C

4: 71 percent / 2-nitrophenol; molecular sieves 4 Angstroem / 24 h / 130 °C

5: 97 percent / diisobutylaluminum hydride / toluene / 0.67 h / 0 °C

6: 98 percent / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 20 °C

7: 77 percent / sodium; naphthalene / tetrahydrofuran / 1.5 h / -40 °C

With sodium tetrahydroborate; cerium(III) chloride; naphthalene; 4 A molecular sieve; sodium; diisobutylaluminium hydride; triphenylphosphine; pyridinium chlorochromate; 2-hydroxynitrobenzene; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; toluene; 3: Luche reduction / 4: Johnson-Claisen rearrangement / 6: Mitsunobu amination;
DOI:10.1016/j.tet.2007.05.041

Reference yield:

: 712280-92-7
(4S,6R)-4-benzyloxy-6-(tert-butyldimethylsilyloxy)-3-[3',4'-(methylenedioxy)phenyl]-2-cyclohexen-1-one

: 712280-97-2
N-(tert-butoxycarbonyl)-N-{2-(1'S,4'R,6'S)-1'-[3,4-(methylenedioxy)phenyl]-4'-(tert-butyldimethylsilyloxy)-2'-cyclohexenyl}ethyl amine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.87 g / CeCl₃*7H₂O; NaBH₄ / methanol; CH₂Cl₂ / 0.5 h / -78 °C

2: 71 percent / 2-nitrophenol; molecular sieves 4 Angstroem / 24 h / 130 °C

3: 97 percent / diisobutylaluminum hydride / toluene / 0.67 h / 0 °C

4: 98 percent / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h / 20 °C

5: 77 percent / sodium; naphthalene / tetrahydrofuran / 1.5 h / -40 °C

With sodium tetrahydroborate; cerium(III) chloride; naphthalene; 4 A molecular sieve; sodium; diisobutylaluminium hydride; triphenylphosphine; 2-hydroxynitrobenzene; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; toluene; 1: Luche reduction / 2: Johnson-Claisen rearrangement / 4: Mitsunobu amination;
DOI:10.1016/j.tet.2007.05.041