N₄-[2'-(trifluoromethoxy)phenyl]-N₂-(4'-carboxyphenyl)pyrimidine-2,4-diamine hydrochloride

Base Information

• Chemical Name: N₄-[2'-(trifluoromethoxy)phenyl]-N₂-(4'-carboxyphenyl)pyrimidine-2,4-diamine hydrochloride
• CAS No.: 1395885-35-4
• Molecular Formula: C₁₈H₁₃F₃N₄O₃*ClH
• Molecular Weight: 426.782

Synonyms:N₄-[2'-(trifluoromethoxy)phenyl]-N₂-(4'-carboxyphenyl)pyrimidine-2,4-diamine hydrochloride

Chemical Property of N₄-[2'-(trifluoromethoxy)phenyl]-N₂-(4'-carboxyphenyl)pyrimidine-2,4-diamine hydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of N₄-[2'-(trifluoromethoxy)phenyl]-N₂-(4'-carboxyphenyl)pyrimidine-2,4-diamine hydrochloride

There total 2 articles about N₄-[2'-(trifluoromethoxy)phenyl]-N₂-(4'-carboxyphenyl)pyrimidine-2,4-diamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

N4-(2-(trifluoromethoxy)phenyl)-2-chloropyrimidine-4-amine (1285236-06-7) + 4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → N4-[2'-(trifluoromethoxy)phenyl]-N2-(4'-carboxyphenyl)pyrimidine-2,4-diamine hydrochloride (1395885-35-4)

Guidance literature:

In ethanol; at 150 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1021/jm300334d

Reference yield:

2-trifluoromethoxy aniline (1535-75-7) → N4-[2'-(trifluoromethoxy)phenyl]-N2-(4'-carboxyphenyl)pyrimidine-2,4-diamine hydrochloride (1395885-35-4)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 20 h / 125 °C / Sealed tube

2: ethanol / 0.33 h / 150 °C / Microwave irradiation

With N-ethyl-N,N-diisopropylamine; In ethanol; butan-1-ol;

DOI:10.1021/jm300334d

upstream raw materials:

N⁴-(2-(trifluoromethoxy)phenyl)-2-chloropyrimidine-4-amine

4-amino-benzoic acid

2-trifluoromethoxy aniline

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