(S)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolid-2-one

Base Information

Chemical Name:(S)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolid-2-one
CAS No.:1345879-89-1
Molecular Formula:C₁₄H₁₆ClFN₂O₃
Molecular Weight:314.744
Hs Code.:

Synonyms:(S)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolid-2-one

Suppliers and Price of (S)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolid-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolid-2-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolid-2-one

There total 6 articles about (S)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolid-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 224323-51-7
3-fluoro-4-(morpholin-4-yl)-phenyl isocyanate

: 67843-74-7,24969-06-0,13403-37-7
(S)-epichlorohydrin

: 1345879-89-1
(S)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolid-2-one

Guidance literature:: With Tributylphosphine oxide; lithium bromide; In o-xylene; for 0.75h; Inert atmosphere; Reflux;
DOI:10.1016/j.tetlet.2015.10.082

Reference yield:

: 224323-51-7
3-fluoro-4-(morpholin-4-yl)-phenyl isocyanate

: 67843-74-7,24969-06-0,13403-37-7
(S)-epichlorohydrin

: C₁₄H₁₆BrFN₂O₃

: 1345879-89-1
(S)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolid-2-one

Guidance literature:: Tributylphosphine oxide; lithium bromide; In o-xylene; Reflux;

Reference yield:

: 3-fluoro-4-(morpholin-4-yl)benzoic acid

: 1345879-89-1
(S)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolid-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; phosphorus pentachloride / dichloromethane / 1.5 h / Reflux; Inert atmosphere

2: sodium azide / water; acetone / 0.17 h / 20 °C

4: lithium bromide; Tributylphosphine oxide / o-xylene / 0.75 h / Inert atmosphere; Reflux

With hydrogenchloride; sodium azide; Tributylphosphine oxide; phosphorus pentachloride; lithium bromide; In dichloromethane; o-xylene; water; acetone; 3: |Curtius Rearrangement;
DOI:10.1016/j.tetlet.2015.10.082