(5S,9R)-isopropyl 1,3-dibenzyl-9-(4-(benzyloxy)butyl)-2,4-dioxo-1,3-diazaspiro[4.4]non-7-ene-7-carboxylate

Base Information

Chemical Name:(5S,9R)-isopropyl 1,3-dibenzyl-9-(4-(benzyloxy)butyl)-2,4-dioxo-1,3-diazaspiro[4.4]non-7-ene-7-carboxylate
CAS No.:1315576-40-9
Molecular Formula:C₃₆H₄₀N₂O₅
Molecular Weight:580.724
Hs Code.:

Synonyms:(5S,9R)-isopropyl 1,3-dibenzyl-9-(4-(benzyloxy)butyl)-2,4-dioxo-1,3-diazaspiro[4.4]non-7-ene-7-carboxylate

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Chemical Property of (5S,9R)-isopropyl 1,3-dibenzyl-9-(4-(benzyloxy)butyl)-2,4-dioxo-1,3-diazaspiro[4.4]non-7-ene-7-carboxylate

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Technology Process of (5S,9R)-isopropyl 1,3-dibenzyl-9-(4-(benzyloxy)butyl)-2,4-dioxo-1,3-diazaspiro[4.4]non-7-ene-7-carboxylate

There total 3 articles about (5S,9R)-isopropyl 1,3-dibenzyl-9-(4-(benzyloxy)butyl)-2,4-dioxo-1,3-diazaspiro[4.4]non-7-ene-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1315575-80-4
(+/-)-isopropyl 8-(benzyloxy)octa-2,3-dienoate

: 120803-26-1
1,3-dibenzyl-5-methyleneimidazolidine-2,4-dione

: 1315576-24-9
C₃₆H₄₀N₂O₅

: 1315576-40-9
(5S,9R)-isopropyl 1,3-dibenzyl-9-(4-(benzyloxy)butyl)-2,4-dioxo-1,3-diazaspiro[4.4]non-7-ene-7-carboxylate

Guidance literature:: (+/-)-isopropyl 8-(benzyloxy)octa-2,3-dienoate; 1,3-dibenzyl-5-methyleneimidazolidine-2,4-dione; With C₄₀H₂₉P; In di-isopropyl ether; at 20 ℃; for 24h;

With tert.-butylhydroperoxide; In 2,2,4-trimethylpentane; di-isopropyl ether; for 0.0166667h; optical yield given as %ee; stereoselective reaction;
DOI:10.1021/ja2049012

Reference yield:

: 110212-61-8
isopropyl 2-(triphenylphosphoranylidene)acetate

: 1315576-40-9
(5S,9R)-isopropyl 1,3-dibenzyl-9-(4-(benzyloxy)butyl)-2,4-dioxo-1,3-diazaspiro[4.4]non-7-ene-7-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.02 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C

2.1: C₄₀H₂₉P / di-isopropyl ether / 24 h / 20 °C

2.2: 0.02 h

With C₄₀H₂₉P; triethylamine; In dichloromethane; di-isopropyl ether;
DOI:10.1021/ja2049012

Reference yield:

: 162439-38-5
6-benzyloxyhexanoic acid chloride

: 1315576-24-9
C₃₆H₄₀N₂O₅

: 1315576-40-9
(5S,9R)-isopropyl 1,3-dibenzyl-9-(4-(benzyloxy)butyl)-2,4-dioxo-1,3-diazaspiro[4.4]non-7-ene-7-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.02 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C

2.1: C₄₀H₂₉P / di-isopropyl ether / 24 h / 20 °C

2.2: 0.02 h

With C₄₀H₂₉P; triethylamine; In dichloromethane; di-isopropyl ether;
DOI:10.1021/ja2049012