5-(benzo[d][1,3]dioxol-5-yl)-3-bromo-1-(4-fluorophenyl)-1H-pyrazole

Base Information

• Chemical Name: 5-(benzo[d][1,3]dioxol-5-yl)-3-bromo-1-(4-fluorophenyl)-1H-pyrazole
• CAS No.: 1324008-97-0
• Molecular Formula: C₁₆H₁₀BrFN₂O₂
• Molecular Weight: 361.17
• Mol file: 1324008-97-0.mol

Synonyms:5-(benzo[d][1,3]dioxol-5-yl)-3-bromo-1-(4-fluorophenyl)-1H-pyrazole

Chemical Property of 5-(benzo[d][1,3]dioxol-5-yl)-3-bromo-1-(4-fluorophenyl)-1H-pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(benzo[d][1,3]dioxol-5-yl)-3-bromo-1-(4-fluorophenyl)-1H-pyrazole

There total 4 articles about 5-(benzo[d][1,3]dioxol-5-yl)-3-bromo-1-(4-fluorophenyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-bromo-1-(4-fluorophenyl)-5-iodo-1H-pyrazole (1324008-92-5) + 3,4-(methylenedioxy)-benzeneboronic acid (94839-07-3) → 5-(benzo[d][1,3]dioxol-5-yl)-3-bromo-1-(4-fluorophenyl)-1H-pyrazole (1324008-97-0)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 50 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201100119

Reference yield:

C8H4FIN2O2 (1324008-79-8) → 5-(benzo[d][1,3]dioxol-5-yl)-3-bromo-1-(4-fluorophenyl)-1H-pyrazole (1324008-97-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 5,5-dimethyl-1,3-cyclohexadiene / Reflux

2: sulfuric acid; water / 0.5 h / 180 °C

3: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 50 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; water; In 5,5-dimethyl-1,3-cyclohexadiene; water; N,N-dimethyl-formamide; 3: Suzuki-type cross coupling;

DOI:10.1002/ejoc.201100119

Reference yield:

ethyl 3-bromo-1-(4-fluorophenyl)-5-iodo-1H-pyrazole-4-carboxylate (1324008-85-6) → 5-(benzo[d][1,3]dioxol-5-yl)-3-bromo-1-(4-fluorophenyl)-1H-pyrazole (1324008-97-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; water / 0.5 h / 180 °C

2: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 50 °C / Inert atmosphere

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; water; In water; N,N-dimethyl-formamide; 2: Suzuki-type cross coupling;

DOI:10.1002/ejoc.201100119

upstream raw materials:

ethyl 3-bromo-1-(4-fluorophenyl)-5-iodo-1H-pyrazole-4-carboxylate

3-bromo-1-(4-fluorophenyl)-5-iodo-1H-pyrazole

3,4-(methylenedioxy)-benzeneboronic acid

C₈H₄FIN₂O₂