3-[2-(3,4-dichlorophenyl)ethyl]-N-(1,1-dimethylethyl)-2-pyridine carboxamide

Base Information

• Chemical Name: 3-[2-(3,4-dichlorophenyl)ethyl]-N-(1,1-dimethylethyl)-2-pyridine carboxamide
• CAS No.: 111108-58-8
• Molecular Formula: C₁₈H₂₀Cl₂N₂O
• Molecular Weight: 351.276
• Mol file: 111108-58-8.mol

Synonyms:3-[2-(3,4-dichlorophenyl)ethyl]-N-(1,1-dimethylethyl)-2-pyridine carboxamide

Chemical Property of 3-[2-(3,4-dichlorophenyl)ethyl]-N-(1,1-dimethylethyl)-2-pyridine carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[2-(3,4-dichlorophenyl)ethyl]-N-(1,1-dimethylethyl)-2-pyridine carboxamide

There total 1 articles about 3-[2-(3,4-dichlorophenyl)ethyl]-N-(1,1-dimethylethyl)-2-pyridine carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-Dichlorophenylmethyl chloride (102-47-6) + N-tert-butyl-3-methylpyridine-2-carboxamide (32998-95-1) → 3-[2-(3,4-dichlorophenyl)ethyl]-N-(1,1-dimethylethyl)-2-pyridine carboxamide (111108-58-8)

Guidance literature:

With n-butyllithium; Multistep reaction; 1.) THF, -40 deg C;

DOI:10.1021/jm00105a069

Reference yield: 91.6%

3-[2-(3,4-dichlorophenyl)ethyl]-N-(1,1-dimethylethyl)-2-pyridine carboxamide (111108-58-8) → 3-[2-(3,4-Dichlorophenyl)ethyl]-2-pyridinecarbonitrile (111108-59-9)

Guidance literature:

With potassium carbonate; In trichlorophosphate;

Reference yield:

3-[2-(3,4-dichlorophenyl)ethyl]-N-(1,1-dimethylethyl)-2-pyridine carboxamide (111108-58-8) → {3-[2-(3,4-Dichloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone (111108-60-2)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃ / Heating

2: 2.) aq. HCl / 1.) THF, reflux

With hydrogenchloride; trichlorophosphate;

DOI:10.1021/jm00105a069

upstream raw materials:

3,4-Dichlorophenylmethyl chloride

N-tert-butyl-3-methylpyridine-2-carboxamide

Downstream raw materials:

3-[2-(3,4-Dichlorophenyl)ethyl]-2-pyridinecarbonitrile

{3-[2-(3,4-Dichloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone