(R)-(-)-1-(4-benzyloxyphenyl)-2-benzylaminopropane

Base Information

• Chemical Name: (R)-(-)-1-(4-benzyloxyphenyl)-2-benzylaminopropane
• CAS No.: 943962-11-6
• Molecular Formula: C₂₃H₂₅NO
• Molecular Weight: 331.458
• Mol file: 943962-11-6.mol

Synonyms:(R)-(-)-1-(4-benzyloxyphenyl)-2-benzylaminopropane

Chemical Property of (R)-(-)-1-(4-benzyloxyphenyl)-2-benzylaminopropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(-)-1-(4-benzyloxyphenyl)-2-benzylaminopropane

There total 5 articles about (R)-(-)-1-(4-benzyloxyphenyl)-2-benzylaminopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

1-(4-benzyloxyphenyl)-2-benzylaminopropane (65033-31-0) → (R)-(-)-1-(4-benzyloxyphenyl)-2-benzylaminopropane (943962-11-6)

Guidance literature:

With (R)-Mandelic Acid; In methanol; Heating;

DOI:10.1021/jm070030d

Reference yield:

1-(4-benzyloxyphenyl)propan-2-one (5586-92-5) → (R)-(-)-1-(4-benzyloxyphenyl)-2-benzylaminopropane (943962-11-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / HOAc; NaBH(AcO)3 / CH₂Cl₂ / 0 - 20 °C

2: 28 percent / (R)-(-)-mandelic acid / methanol / Heating

With (R)-Mandelic Acid; sodium tris(acetoxy)borohydride; acetic acid; In methanol; dichloromethane;

DOI:10.1021/jm070030d

Reference yield:

benzylamine (100-46-9) → (R)-(-)-1-(4-benzyloxyphenyl)-2-benzylaminopropane (943962-11-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / HOAc; NaBH(AcO)3 / CH₂Cl₂ / 0 - 20 °C

2: 28 percent / (R)-(-)-mandelic acid / methanol / Heating

With (R)-Mandelic Acid; sodium tris(acetoxy)borohydride; acetic acid; In methanol; dichloromethane;

DOI:10.1021/jm070030d

upstream raw materials:

1-(4-benzyloxyphenyl)-2-benzylaminopropane

1-(4-benzyloxyphenyl)propan-2-one

benzylamine

Downstream raw materials:

C₄₅H₄₅NO₄

C₄₅H₄₅NO₄

(S,R)-5-(1-hydroxy-2-{[2-(4-hydroxyphenyl)-1-methylethyl]amino}ethyl)benzene-1,3-diol

(R,R)-(-)-Fenoterol