1H-Purin-2-amine,6-(1H-imidazol-1-yl)-(9CI)

Base Information

• Chemical Name: 1H-Purin-2-amine,6-(1H-imidazol-1-yl)-(9CI)
• CAS No.: 891497-81-7
• Molecular Formula: C8H7 N7
• Molecular Weight: 201.18808
• Mol file: 891497-81-7.mol

Synonyms:1H-Purin-2-amine,6-(1H-imidazol-1-yl)- (9CI)

Chemical Property of 1H-Purin-2-amine,6-(1H-imidazol-1-yl)-(9CI)

Chemical Property:

• PSA: 98.30000
• LogP: 0.70200

Purity/Quality:

99% ^*data from raw suppliers

6-(1H-Imidazol-1-yl)-7H-purin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Purin-2-amine,6-(1H-imidazol-1-yl)-(9CI)

There total 2 articles about 1H-Purin-2-amine,6-(1H-imidazol-1-yl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(6-imidazol-1-yl-9-trityl-9H-purin-2-yl)-trityl-amine → 2-amino-6-(imidazol-1-yl)purine (891497-81-7)

Guidance literature:

With trifluoroacetic acid; In water; at 0 ℃; for 4h;

DOI:10.1021/jo060340o

Reference yield:

2-amino-1,9-dihydro-6H-purin-6-one (73-40-5) → 2-amino-6-(imidazol-1-yl)purine (891497-81-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: HMDS; (NH₄)2SO₄ / 24 h / Heating

1.2: acetonitrile / 48 h / Heating

2.1: PPh₃; I₂; EtN(iPr)2 / toluene / 95 °C

3.1: 400 mg / TFA / H₂O / 4 h / 0 °C

With ammonium sulfate; iodine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; trifluoroacetic acid; In water; toluene;

DOI:10.1021/jo060340o

Reference yield: 68.0%

2-amino-6-(imidazol-1-yl)purine (891497-81-7) + iodomethylbenzene (620-05-3) → 2-amino-9-benzyl-6-(imidazol-1-yl)purine

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 5.5h;

DOI:10.1021/jo061759h

upstream raw materials:

2-amino-1,9-dihydro-6H-purin-6-one

Refernces

• 1、 -. "METHODS FOR SELECTIVE N-9 GLYCOSYLATION OF PURINES". Page/Page column 55. . Retrieved 2010/11/25.