(2S)-1-tert-butyloxycarbonyl-2-((tert-butyldiphenylsilyl)oxymethyl)-3,3-dimethyl-azetidine

Base Information

Chemical Name:(2S)-1-tert-butyloxycarbonyl-2-((tert-butyldiphenylsilyl)oxymethyl)-3,3-dimethyl-azetidine
CAS No.:1648572-36-4
Molecular Formula:C₂₇H₃₉NO₃Si
Molecular Weight:453.697
Hs Code.:

Synonyms:(2S)-1-tert-butyloxycarbonyl-2-((tert-butyldiphenylsilyl)oxymethyl)-3,3-dimethyl-azetidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-1-tert-butyloxycarbonyl-2-((tert-butyldiphenylsilyl)oxymethyl)-3,3-dimethyl-azetidine

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Technology Process of (2S)-1-tert-butyloxycarbonyl-2-((tert-butyldiphenylsilyl)oxymethyl)-3,3-dimethyl-azetidine

There total 7 articles about (2S)-1-tert-butyloxycarbonyl-2-((tert-butyldiphenylsilyl)oxymethyl)-3,3-dimethyl-azetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 150943-17-2
(2R)-1-(tert-butyloxycarbonyl)-2-((tert-butyldiphenylsilyl)oxymethyl)-3-azetidinone

: 1648572-36-4
(2S)-1-tert-butyloxycarbonyl-2-((tert-butyldiphenylsilyl)oxymethyl)-3,3-dimethyl-azetidine

Guidance literature:: With pyridine; In tetrahydrofuran; at -40 - 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.3762/bjoc.10.110

Reference yield: 50.0%

: 1271-66-5
dimethyltitanocene

: 150943-17-2
(2R)-1-(tert-butyloxycarbonyl)-2-((tert-butyldiphenylsilyl)oxymethyl)-3-azetidinone

: 1648572-35-3
(2S)-1-(tert-butyloxycarbonyl)-2-(tert-butyldiphenylsilyloxymethyl)-3-methylideneazetidine

: 1648572-36-4
(2S)-1-tert-butyloxycarbonyl-2-((tert-butyldiphenylsilyl)oxymethyl)-3,3-dimethyl-azetidine

Guidance literature:: Inert atmosphere;
DOI:10.3762/bjoc.10.110

Reference yield:

: N-Boc-O-TBDPS-(R)-serine

: 1648572-36-4
(2S)-1-tert-butyloxycarbonyl-2-((tert-butyldiphenylsilyl)oxymethyl)-3,3-dimethyl-azetidine

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methyl-morpholine / dichloromethane / 1 h / -5 °C / Inert atmosphere

2: acetonitrile; hexane / 43 h / 4 °C / Inert atmosphere

3: dirhodium tetraacetate / dichloromethane / -95 - 20 °C / Inert atmosphere

4: pyridine / tetrahydrofuran / 1.5 h / -40 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; pyridine; dirhodium tetraacetate; In tetrahydrofuran; hexane; dichloromethane; acetonitrile;
DOI:10.3762/bjoc.10.110