(S)-2,6-diamino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl)hexanamide hydrochloride

Base Information

Chemical Name:(S)-2,6-diamino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl)hexanamide hydrochloride
CAS No.:1335122-83-2
Molecular Formula:C₁₅H₂₅N₅O₄*ClH
Molecular Weight:375.856
Hs Code.:

Synonyms:(S)-2,6-diamino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl)hexanamide hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2,6-diamino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl)hexanamide hydrochloride

Chemical Property:

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Technology Process of (S)-2,6-diamino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl)hexanamide hydrochloride

There total 6 articles about (S)-2,6-diamino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl)hexanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: C₃₀H₄₉N₅O₁₀

: 1335122-83-2
(S)-2,6-diamino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl)hexanamide hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 4h;
DOI:10.1016/j.bmc.2011.07.008

Reference yield:

: 1186120-57-9
tert-butyl (1S,2R)-3-bromo-1-hydroxy-1-(4-nitrophenyl)propan-2-ylcarbamate

: 1335122-83-2
(S)-2,6-diamino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl)hexanamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide / N,N-dimethyl-formamide / 12 h / 65 °C / Inert atmosphere

2: triphenylphosphine / tetrahydrofuran; water / 24 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane

4: hydrogenchloride / ethyl acetate / 4 h / 20 °C

With hydrogenchloride; sodium azide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.07.008

Reference yield:

: 1186120-58-0
tert-butyl(1S,2S)-3-azido-1-hydroxy-1-(4-nitrophenyl)propan-2-ylcarbamate

: 1335122-83-2
(S)-2,6-diamino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl)hexanamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine / tetrahydrofuran; water / 24 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane

3: hydrogenchloride / ethyl acetate / 4 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; ethyl acetate;
DOI:10.1016/j.bmc.2011.07.008