(2R,3S)-5-(benzylthio)-2-(hydroxymethyl)tetrahydrothiophen-3-ol

Base Information

• Chemical Name: (2R,3S)-5-(benzylthio)-2-(hydroxymethyl)tetrahydrothiophen-3-ol
• CAS No.: 134700-25-7
• Molecular Formula: C₁₂H₁₆O₂S₂
• Molecular Weight: 256.39
• Mol file: 134700-25-7.mol

Synonyms:(2R,3S)-5-(benzylthio)-2-(hydroxymethyl)tetrahydrothiophen-3-ol

Chemical Property of (2R,3S)-5-(benzylthio)-2-(hydroxymethyl)tetrahydrothiophen-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S)-5-(benzylthio)-2-(hydroxymethyl)tetrahydrothiophen-3-ol

There total 2 articles about (2R,3S)-5-(benzylthio)-2-(hydroxymethyl)tetrahydrothiophen-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

→ (2R,3S)-5-(benzylthio)-2-(hydroxymethyl)tetrahydrothiophen-3-ol (134700-25-7)

Guidance literature:

With lithium hydroxide monohydrate; water; In tetrahydrofuran; for 70h; Reflux;

Reference yield: 82.0%

benzyl 3,5-di-O-benzyl-2-deoxy-1,4-dithio-D-erythro-pentofuranoside (134938-97-9) → (2R,3S)-5-(benzylthio)-2-(hydroxymethyl)tetrahydrothiophen-3-ol (134700-25-7)

Guidance literature:

With boron tribromide; In dichloromethane;

DOI:10.1080/15257779508012449

Reference yield: 89.0%

4-methyl-benzoyl chloride (874-60-2) + (2R,3S)-5-(benzylthio)-2-(hydroxymethyl)tetrahydrothiophen-3-ol (134700-25-7) → benzyl 2-deoxy-1,4-dithio-3,5-di-O-p-toluoyl-D-erythro-pentofuranoside (134939-04-1)

Guidance literature:

With pyridine;

DOI:10.1080/15257779508012449

upstream raw materials:

benzyl 3,5-di-O-benzyl-2-deoxy-1,4-dithio-D-erythro-pentofuranoside

Downstream raw materials:

benzyl 2-deoxy-1,4-dithio-3,5-di-O-p-toluoyl-D-erythro-pentofuranoside

(2R,3S)-5-Benzylsulfanyl-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-ol

benzyl 2-deoxy-1,4-dithio-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-D-erythro-pentofuranoside

benzyl 2-deoxy-3,5-O-(di-tert-butylsilylene)-1,4-dithio-D-erythro-pentofuranoside