(2S)-1-(phenylacetyl)-N-{3-[6-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)-1H-indol-2-yl]phenyl}pyrrolidine-2-carboxamide

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Chemical Name:(2S)-1-(phenylacetyl)-N-{3-[6-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)-1H-indol-2-yl]phenyl}pyrrolidine-2-carboxamide
CAS No.:1246469-67-9
Molecular Formula:C₄₀H₃₉N₅O₄
Molecular Weight:653.781
Hs Code.:

Synonyms:(2S)-1-(phenylacetyl)-N-{3-[6-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)-1H-indol-2-yl]phenyl}pyrrolidine-2-carboxamide

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Chemical Property of (2S)-1-(phenylacetyl)-N-{3-[6-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)-1H-indol-2-yl]phenyl}pyrrolidine-2-carboxamide

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Technology Process of (2S)-1-(phenylacetyl)-N-{3-[6-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)-1H-indol-2-yl]phenyl}pyrrolidine-2-carboxamide

There total 2 articles about (2S)-1-(phenylacetyl)-N-{3-[6-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)-1H-indol-2-yl]phenyl}pyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246471-74-8
C₁₄H₁₃N₃

: 2752-38-7
(S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid

: 1246469-67-9
(2S)-1-(phenylacetyl)-N-{3-[6-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)-1H-indol-2-yl]phenyl}pyrrolidine-2-carboxamide

Guidance literature:: C₁₄H₁₃N₃; (S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 0.0833333h;

With HATU; In acetonitrile; at 20 ℃;

Reference yield:

: 5459-50-7
2-iodo-5-nitroaniline

: 1246469-67-9
(2S)-1-(phenylacetyl)-N-{3-[6-({[(2S)-1-(phenylacetyl)pyrrolidin-2-yl]carbonyl}amino)-1H-indol-2-yl]phenyl}pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 25 °C / Inert atmosphere

2: palladium dichloride; iron(III) chloride / 1,2-dichloro-ethane / 2 h / 80 °C

3: hydrogen; palladium on activated charcoal / ethanol / 1 h

4: hydrogenchloride; water / 1 h / 80 °C

5: HATU; N-ethyl-N,N-diisopropylamine / acetonitrile / 25 °C

With hydrogenchloride; iron(III) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium on activated charcoal; water; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium dichloride; In tetrahydrofuran; ethanol; 1,2-dichloro-ethane; acetonitrile;