5-(4-chloro-3-methylphenyl)-1-phenyl-N-(1,3,3-trimethylbicyclo-[2.2.1]heptan-2-yl)-1H-pyrazole-3-carboxamide

Base Information

Chemical Name:5-(4-chloro-3-methylphenyl)-1-phenyl-N-(1,3,3-trimethylbicyclo-[2.2.1]heptan-2-yl)-1H-pyrazole-3-carboxamide
CAS No.:1449691-94-4
Molecular Formula:C₂₇H₃₀ClN₃O
Molecular Weight:448.008
Hs Code.:

Synonyms:5-(4-chloro-3-methylphenyl)-1-phenyl-N-(1,3,3-trimethylbicyclo-[2.2.1]heptan-2-yl)-1H-pyrazole-3-carboxamide

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Chemical Property of 5-(4-chloro-3-methylphenyl)-1-phenyl-N-(1,3,3-trimethylbicyclo-[2.2.1]heptan-2-yl)-1H-pyrazole-3-carboxamide

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Technology Process of 5-(4-chloro-3-methylphenyl)-1-phenyl-N-(1,3,3-trimethylbicyclo-[2.2.1]heptan-2-yl)-1H-pyrazole-3-carboxamide

There total 5 articles about 5-(4-chloro-3-methylphenyl)-1-phenyl-N-(1,3,3-trimethylbicyclo-[2.2.1]heptan-2-yl)-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: C₁₇H₁₂Cl₂N₂O

: 192702-77-5,770696-39-4
(1,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl)-amide

: 1449691-94-4
5-(4-chloro-3-methylphenyl)-1-phenyl-N-(1,3,3-trimethylbicyclo-[2.2.1]heptan-2-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm400070u

Reference yield:

: C₁₃H₁₅ClO₃

: 1449691-94-4
5-(4-chloro-3-methylphenyl)-1-phenyl-N-(1,3,3-trimethylbicyclo-[2.2.1]heptan-2-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 16 h / 80 °C / Sealed tube; Inert atmosphere

2.1: dichloromethane / Inert atmosphere

3.1: sodium hydroxide / methanol; tetrahydrofuran / 2.5 h / 80 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: thionyl chloride / toluene / 1.5 h / Inert atmosphere; Reflux

5.1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With thionyl chloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jm400070u

Reference yield:

: 1329548-59-5
5-(4-chloro-3-methylphenyl)-1-phenyl-1H-pyrazole-3-carboxylic acid

: 1449691-94-4
5-(4-chloro-3-methylphenyl)-1-phenyl-N-(1,3,3-trimethylbicyclo-[2.2.1]heptan-2-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / toluene / 1.5 h / Inert atmosphere; Reflux

2: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

With thionyl chloride; triethylamine; In dichloromethane; toluene;
DOI:10.1021/jm400070u