4-tert-butyl-N-[4-(3-methoxy-phenylsulfanyl)-5-(4-oxo-butyl)-isoxazol-3-yl]-benzenesulfonamide

Base Information

Chemical Name:4-tert-butyl-N-[4-(3-methoxy-phenylsulfanyl)-5-(4-oxo-butyl)-isoxazol-3-yl]-benzenesulfonamide
CAS No.:188940-39-8
Molecular Formula:C₂₄H₂₈N₂O₅S₂
Molecular Weight:488.629
Hs Code.:

4-<i>tert</i>-butyl-<i>N</i>-[4-(3-methoxy-phenylsulfanyl)-5-(4-oxo-butyl)-isoxazol-3-yl]-benzenesulfonamide

Synonyms:4-tert-butyl-N-[4-(3-methoxy-phenylsulfanyl)-5-(4-oxo-butyl)-isoxazol-3-yl]-benzenesulfonamide

Suppliers and Price of 4-tert-butyl-N-[4-(3-methoxy-phenylsulfanyl)-5-(4-oxo-butyl)-isoxazol-3-yl]-benzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-tert-butyl-N-[4-(3-methoxy-phenylsulfanyl)-5-(4-oxo-butyl)-isoxazol-3-yl]-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-tert-butyl-N-[4-(3-methoxy-phenylsulfanyl)-5-(4-oxo-butyl)-isoxazol-3-yl]-benzenesulfonamide

There total 16 articles about 4-tert-butyl-N-[4-(3-methoxy-phenylsulfanyl)-5-(4-oxo-butyl)-isoxazol-3-yl]-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 188940-50-3
4-tert-butyl-N-[5-(3-cyano-propyl)-4-(3-methoxy-phenylsulfanyl)-isoxazol-3-yl]-benzenesulfonamide

: 188940-39-8
4-tert-butyl-N-[4-(3-methoxy-phenylsulfanyl)-5-(4-oxo-butyl)-isoxazol-3-yl]-benzenesulfonamide

Guidance literature:: 4-tert-butyl-N-[5-(3-cyano-propyl)-4-(3-methoxy-phenylsulfanyl)-isoxazol-3-yl]-benzenesulfonamide; With diisobutylaluminium hydride; In toluene; at -78 - 20 ℃;

With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;
DOI:10.1016/S0960-894X(00)00366-8

Reference yield:

: 5390-04-5
pent-1-yn-5-ol

: 188940-39-8
4-tert-butyl-N-[4-(3-methoxy-phenylsulfanyl)-5-(4-oxo-butyl)-isoxazol-3-yl]-benzenesulfonamide

Guidance literature:: Multi-step reaction with 14 steps

1.1: 97 percent / imidazole / CH₂Cl₂ / 20 °C

2.1: 76 percent / Et₃N / 20 °C

3.1: 81 percent / aq. NaOH / methanol / 20 °C

4.1: SOCl₂; pyridine / CH₂Cl₂ / 0 °C

5.1: NaN₃ / acetone; H₂O / 0 °C

6.1: toluene / Heating

7.1: n-BuLi / tetrahydrofuran / -78 - 20 °C

7.2: 67 percent / tetrahydrofuran / -78 °C

8.1: n-Bu₄NF / tetrahydrofuran / 20 °C

9.1: DMAP; pyridine / CH₂Cl₂ / 20 °C

10.1: TFA / 20 °C

11.1: 64 percent / DMAP; pyridine / 50 °C

12.1: 92 percent / aq. NaOH / methanol; tetrahydrofuran / 20 °C

13.1: dimethylformamide / 80 °C

14.1: DIBAH / toluene / -78 - 20 °C

14.2: aq. NaOH / methanol; tetrahydrofuran / 20 °C

With pyridine; 1H-imidazole; dmap; sodium hydroxide; n-butyllithium; thionyl chloride; sodium azide; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; 1.1: silylation / 2.1: Cycloaddition / 3.1: Hydrolysis / 4.1: Chlorination / 5.1: Substitution / 6.1: Rearrangement / 7.1: Metallation / 7.2: Condensation / 8.1: desilylation / 9.1: Acetylation / 10.1: acidolysis / 11.1: sulfonylation / 12.1: Deacetylation / 13.1: Substitution / 14.1: Reduction / 14.2: Hydrolysis;
DOI:10.1016/S0960-894X(00)00366-8

Reference yield:

: 59014-89-0
bis(3-methoxyphenyl)disulfide

: 188940-39-8
4-tert-butyl-N-[4-(3-methoxy-phenylsulfanyl)-5-(4-oxo-butyl)-isoxazol-3-yl]-benzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-BuLi / tetrahydrofuran / -78 - 20 °C

1.2: 67 percent / tetrahydrofuran / -78 °C

2.1: n-Bu₄NF / tetrahydrofuran / 20 °C

3.1: DMAP; pyridine / CH₂Cl₂ / 20 °C

4.1: TFA / 20 °C

5.1: 64 percent / DMAP; pyridine / 50 °C

6.1: 92 percent / aq. NaOH / methanol; tetrahydrofuran / 20 °C

7.1: dimethylformamide / 80 °C

8.1: DIBAH / toluene / -78 - 20 °C

8.2: aq. NaOH / methanol; tetrahydrofuran / 20 °C

With pyridine; dmap; sodium hydroxide; n-butyllithium; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: Metallation / 1.2: Condensation / 2.1: desilylation / 3.1: Acetylation / 4.1: acidolysis / 5.1: sulfonylation / 6.1: Deacetylation / 7.1: Substitution / 8.1: Reduction / 8.2: Hydrolysis;
DOI:10.1016/S0960-894X(00)00366-8