Technology Process of (S)-1-((S)-5-Decanoylamino-4-oxo-6-phenyl-hexanoyl)-pyrrolidine-2-carboxylic acid
There total 10 articles about (S)-1-((S)-5-Decanoylamino-4-oxo-6-phenyl-hexanoyl)-pyrrolidine-2-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: Et3N / tetrahydrofuran / 16 h / Ambient temperature
2: pyridine, HOAc / 1 h / 100 °C
3: 0.5 N aq. NaOH / tetrahydrofuran / 4 h / Ambient temperature
4: 78 percent / conc. aq. HCl, acetic acid / 24 h / Heating
5: HCl / 18 h
6: 74 percent / Na2CO3 / H2O / 1 h
7: 1N aq. NaOH / methanol / 0.17 h
8: Et3N, DCC / CH2Cl2 / 1.) 0 deg C, 30 min, 2.) RT, 18 h
9: H2, acetic acid / 10percent Pd/C / 16 h / 760 Torr / Ambient temperature
With
pyridine; hydrogenchloride; sodium hydroxide; hydrogen; sodium carbonate; acetic acid; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm00353a005
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 0.5 N aq. NaOH / tetrahydrofuran / 4 h / Ambient temperature
2: 78 percent / conc. aq. HCl, acetic acid / 24 h / Heating
3: HCl / 18 h
4: 74 percent / Na2CO3 / H2O / 1 h
5: 1N aq. NaOH / methanol / 0.17 h
6: Et3N, DCC / CH2Cl2 / 1.) 0 deg C, 30 min, 2.) RT, 18 h
7: H2, acetic acid / 10percent Pd/C / 16 h / 760 Torr / Ambient temperature
With
hydrogenchloride; sodium hydroxide; hydrogen; sodium carbonate; acetic acid; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm00353a005
- Guidance literature:
-
Multi-step reaction with 8 steps
1: pyridine, HOAc / 1 h / 100 °C
2: 0.5 N aq. NaOH / tetrahydrofuran / 4 h / Ambient temperature
3: 78 percent / conc. aq. HCl, acetic acid / 24 h / Heating
4: HCl / 18 h
5: 74 percent / Na2CO3 / H2O / 1 h
6: 1N aq. NaOH / methanol / 0.17 h
7: Et3N, DCC / CH2Cl2 / 1.) 0 deg C, 30 min, 2.) RT, 18 h
8: H2, acetic acid / 10percent Pd/C / 16 h / 760 Torr / Ambient temperature
With
pyridine; hydrogenchloride; sodium hydroxide; hydrogen; sodium carbonate; acetic acid; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm00353a005