2-(4-butylphenoxy)-N-isopropyl-N-((3-pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)methylacetamide

Base Information

• Chemical Name: 2-(4-butylphenoxy)-N-isopropyl-N-((3-pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)methylacetamide
• CAS No.: 1401223-32-2
• Molecular Formula: C₂₂H₂₇N₅O₃
• Molecular Weight: 409.488
• Mol file: 1401223-32-2.mol

Synonyms:2-(4-butylphenoxy)-N-isopropyl-N-((3-pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)methylacetamide

Chemical Property of 2-(4-butylphenoxy)-N-isopropyl-N-((3-pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)methylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-butylphenoxy)-N-isopropyl-N-((3-pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)methylacetamide

There total 9 articles about 2-(4-butylphenoxy)-N-isopropyl-N-((3-pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-(4-butylphenoxy)acetyl chloride (1401223-62-8) + N-((3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)methyl)propan-2-amine (1182805-29-3) → 2-(4-butylphenoxy)-N-isopropyl-N-((3-pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)methylacetamide (1401223-32-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.25h;

DOI:10.1021/jm400221d

Reference yield: 78.0%

→ 2-(4-butylphenoxy)-N-isopropyl-N-((3-pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)methylacetamide (1401223-32-2)

Guidance literature:

Reference yield:

4-n-butylphenol (1638-22-8) → 2-(4-butylphenoxy)-N-isopropyl-N-((3-pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)methylacetamide (1401223-32-2)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 80 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: thionyl chloride / benzene / 3 h / Reflux

4: triethylamine / tetrahydrofuran / 0.25 h / 20 °C

With thionyl chloride; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;

DOI:10.1021/jm400221d

upstream raw materials:

2-(4-butylphenoxy)acetyl chloride

N-((3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)methyl)propan-2-amine

4-n-butylphenol

tert-butyl 2-(4-butylphenoxy)acetate