4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(iodoacetyl)glycinanilide

Base Information

• Chemical Name: 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(iodoacetyl)glycinanilide
• CAS No.: 59180-43-7
• Molecular Formula: C₁₈H₁₅Cl₂IN₂O₃
• Molecular Weight: 505.139
• Mol file: 59180-43-7.mol

Synonyms:4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(iodoacetyl)glycinanilide

Chemical Property of 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(iodoacetyl)glycinanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(iodoacetyl)glycinanilide

There total 6 articles about 4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(iodoacetyl)glycinanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.5%

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-(chloroacetyl)glycinanilide (59180-42-6) → 4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-(iodoacetyl)glycinanilide (59180-43-7)

Guidance literature:

With potassium iodide; In acetone; for 1h; Heating;

DOI:10.1021/jm00133a006

Reference yield:

4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-glycinanilide hydrobromide (59180-41-5) → 4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-(iodoacetyl)glycinanilide (59180-43-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / dimethylformamide / Ambient temperature

2: KJ / acetone / Heating

With KJ; In N,N-dimethyl-formamide; acetone;

Reference yield:

4-chloro-2-(o-chlorobenzoyl)-Nα-(benzyloxycarbonyl)glycinanilide (29176-39-4) → 4-chloro-2-(o-chlorobenzoyl)-N-methyl-Nα-(iodoacetyl)glycinanilide (59180-43-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) sodium hydride (50percent oil dispersion) / DMF, RT

2: 96.5 percent / 20percent HBr-AcOH / Ambient temperature

3: 89 percent / dimethylformamide / Ambient temperature

4: KJ / acetone / Heating

With hydrogen bromide; sodium hydride; acetic acid; In N,N-dimethyl-formamide; acetone;

upstream raw materials:

4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(chloroacetyl)glycinanilide

4-chloro-2-(o-chlorobenzoyl)-N^α-(benzyloxycarbonyl)glycinanilide

4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(benzyloxycarbonyl)glycinanilide

4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-glycinanilide hydrobromide

Downstream raw materials:

4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-glycylglycinanilide

N-({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-2-methylamino-acetamide

N-({[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-methyl-carbamoyl}-methyl)-2-diethylamino-acetamide

4-chloro-2-(o-chlorobenzoyl)-N-methyl-N^α-(dimethylglycyl)glycinanilide