1,1-dimethylethyl -7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-5-hydroxy-3-oxo-6-heptenoate

Base Information

Chemical Name:1,1-dimethylethyl -7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-5-hydroxy-3-oxo-6-heptenoate
CAS No.:141046-43-7
Molecular Formula:C₂₈H₃₂FN₃O₄
Molecular Weight:493.578
Hs Code.:

1,1-dimethylethyl <S-(E)>-7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-5-hydroxy-3-oxo-6-heptenoate

Synonyms:1,1-dimethylethyl -7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-5-hydroxy-3-oxo-6-heptenoate

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Chemical Property of 1,1-dimethylethyl -7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-5-hydroxy-3-oxo-6-heptenoate

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Technology Process of 1,1-dimethylethyl -7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-5-hydroxy-3-oxo-6-heptenoate

There total 10 articles about 1,1-dimethylethyl -7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-5-hydroxy-3-oxo-6-heptenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4930-98-7
pyrid-2-ylhydrazine

: 141046-43-7
1,1-dimethylethyl -7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-5-hydroxy-3-oxo-6-heptenoate

Guidance literature:: Multi-step reaction with 7 steps

1: 64 percent / acetic acid / 3 h / 60 °C

2: 50 percent / phosphorus oxychloride / 48 h / 70 °C

3: 1.) sodium hydride / 1.) THF, 0 deg C, 10 min, 2.) THF, -78 deg C - RT, 1 h

4: 66 percent / Raney nickel / formic acid / 60 °C

5: 1.) lithium diisopropylamide, 2.) MgBr₂

6: 81 percent / methanol / 16 h

7: 1.) lithium diisopropylamide / 1.) hexane, THF, -45 deg C, 1 h, 2.) hexane, THF, -45 deg C - -20 deg C, 3.5 h

With sodium hydride; magnesium bromide; lithium diisopropyl amide; trichlorophosphate; nickel; In methanol; formic acid; acetic acid;
DOI:10.1021/jm00089a022

Reference yield:

: 114433-94-2
1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione

: 141046-43-7
1,1-dimethylethyl -7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-5-hydroxy-3-oxo-6-heptenoate

Guidance literature:: Multi-step reaction with 7 steps

1: 64 percent / acetic acid / 3 h / 60 °C

2: 50 percent / phosphorus oxychloride / 48 h / 70 °C

3: 1.) sodium hydride / 1.) THF, 0 deg C, 10 min, 2.) THF, -78 deg C - RT, 1 h

4: 66 percent / Raney nickel / formic acid / 60 °C

5: 1.) lithium diisopropylamide, 2.) MgBr₂

6: 81 percent / methanol / 16 h

7: 1.) lithium diisopropylamide / 1.) hexane, THF, -45 deg C, 1 h, 2.) hexane, THF, -45 deg C - -20 deg C, 3.5 h

With sodium hydride; magnesium bromide; lithium diisopropyl amide; trichlorophosphate; nickel; In methanol; formic acid; acetic acid;
DOI:10.1021/jm00089a022

Reference yield:

: 114433-95-3
2-[5-(4-fluorophenyl)-3-(1-methylethyl)-1H-pyrazol-1-yl]pyridine

: 141046-43-7
1,1-dimethylethyl -7-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-(2-pyridinyl)-1H-pyrazol-4-yl>-5-hydroxy-3-oxo-6-heptenoate

Guidance literature:: Multi-step reaction with 6 steps

1: 50 percent / phosphorus oxychloride / 48 h / 70 °C

2: 1.) sodium hydride / 1.) THF, 0 deg C, 10 min, 2.) THF, -78 deg C - RT, 1 h

3: 66 percent / Raney nickel / formic acid / 60 °C

4: 1.) lithium diisopropylamide, 2.) MgBr₂

5: 81 percent / methanol / 16 h

6: 1.) lithium diisopropylamide / 1.) hexane, THF, -45 deg C, 1 h, 2.) hexane, THF, -45 deg C - -20 deg C, 3.5 h

With sodium hydride; magnesium bromide; lithium diisopropyl amide; trichlorophosphate; nickel; In methanol; formic acid;
DOI:10.1021/jm00089a022