2,2-dimethyl-5-phenylpentan-3-olide

Base Information

• Chemical Name: 2,2-dimethyl-5-phenylpentan-3-olide
• CAS No.: 1376112-28-5
• Molecular Formula: C₁₃H₁₆O₂
• Molecular Weight: 204.269
• Mol file: 1376112-28-5.mol

Synonyms:2,2-dimethyl-5-phenylpentan-3-olide

Chemical Property of 2,2-dimethyl-5-phenylpentan-3-olide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-dimethyl-5-phenylpentan-3-olide

There total 2 articles about 2,2-dimethyl-5-phenylpentan-3-olide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-hydroxy-2,2-dimethyl-5-phenylpentanoic acid (130822-13-8) → 2,2-dimethyl-5-phenylpentan-3-olide (1376112-28-5)

Guidance literature:

With dmap; 2-methyl-6-nitrobenzoic anhydride; sodium hydrogencarbonate; triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jo300139r

Reference yield:

ethyl 3-hydroxy-2,2-dimethyl-5-phenylpentanoate (133270-74-3,133270-75-4,134924-29-1) → 2,2-dimethyl-5-phenylpentan-3-olide (1376112-28-5)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; potassium carbonate / water / 2 h / 20 - 65 °C / Inert atmosphere

2: dmap; 2-methyl-6-nitrobenzoic anhydride; sodium hydrogencarbonate; triethylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With methanol; dmap; 2-methyl-6-nitrobenzoic anhydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; In dichloromethane; water;

DOI:10.1021/jo300139r

upstream raw materials:

3-hydroxy-2,2-dimethyl-5-phenylpentanoic acid

ethyl 3-hydroxy-2,2-dimethyl-5-phenylpentanoate