artelinic acid

Base Information

• Chemical Name: artelinic acid
• CAS No.: 109637-83-4
• Molecular Formula: C₂₃H₃₀O₇
• Molecular Weight: 418.487
• Mol file: 109637-83-4.mol

Synonyms:Benzoicacid, 4-[[(decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl)oxy]methyl]-,[3R-(3a,5ab,6b,8ab,9a,10a,12b,12aR*)]-;3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, benzoic acid deriv.; Artelinicacid; b-Artelinic acid

Chemical Property of artelinic acid

Chemical Property:

• Vapor Pressure: 1.45E-13mmHg at 25°C
• Boiling Point: 564.1°Cat760mmHg
• Flash Point: 192.2°C
• PSA: 83.45000
• Density: 1.33g/cm³
• LogP: 4.10940

Purity/Quality:

98% ^*data from raw suppliers

4-[[(3R,5AS,6R,8AS,9R,10S,12R,12AR)-DECAHYDRO-3,6,9-TRIMETHYL-3,12-EPOXY-12H-PYRANO[4,3-J]-[1,2-BENZODIOXEPIN-10-YL]OXY]METHYL]BENZOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of artelinic acid

There total 22 articles about artelinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

artemisinin + 4-(methoxycarbonyl)benzyl alcohol (6908-41-4,58590-49-1) → artelinic acid (109637-83-4,120020-26-0)

Guidance literature:

artemisinin; 4-(methoxycarbonyl)benzyl alcohol; With sodium tetrahydroborate; chloro-trimethyl-silane; alpha-D-glucopyranose; In 1,4-dioxane; at 25 ℃; for 7h;

With potassium hydroxide; water; In 1,4-dioxane; for 2h;

With water; acetic acid; In 1,4-dioxane; Product distribution / selectivity;

Reference yield: 89.0%

methyl p-<(10-dihydroartemisininoxy)methyl>benzoate (216963-48-3) → p-[(10-dihydroartemisininoxy)methyl]benzoic acid (109637-83-4,120020-26-0)

Guidance literature:

With potassium hydroxide; In methanol; at 20 ℃; for 72h; optical yield given as %de;

DOI:10.1016/j.bcp.2011.04.018

Reference yield: 69.0%

3-hydroxymethyl-benzoic acid (3006-96-0) + dihydroartemisinin (71939-50-9) → p-[(10-dihydroartemisininoxy)methyl]benzoic acid (109637-83-4,120020-26-0)

Guidance literature:

With boron trifluoride diethyl etherate;

DOI:10.1016/j.bmcl.2009.04.100

upstream raw materials:

methyl p-<(10-dihydroartemisininoxy)methyl>benzoate

4-(methoxycarbonyl)benzyl alcohol

dihydroartemisinin

C₁₂H₁₃O₂(CH₃)3(O)(OO)