4-Chlorobenzyl (3S)-3-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline-2-carbodithioate

Base Information

Chemical Name:4-Chlorobenzyl (3S)-3-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline-2-carbodithioate
CAS No.:96086-58-7
Molecular Formula:C₂₀H₁₉ClN₂OS₂
Molecular Weight:402.969
Hs Code.:

Synonyms:4-Chlorobenzyl (3S)-3-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline-2-carbodithioate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Chlorobenzyl (3S)-3-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline-2-carbodithioate

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Technology Process of 4-Chlorobenzyl (3S)-3-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline-2-carbodithioate

There total 4 articles about 4-Chlorobenzyl (3S)-3-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline-2-carbodithioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: 96149-78-9
(S)-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-3-yl)methanol

: 96086-58-7
4-Chlorobenzyl (3S)-3-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline-2-carbodithioate

Guidance literature:: With sodium hydroxide; In CS₂; ethanol;

Reference yield:

: 7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8
(S)-tryptophan methyl ester hydrochloride

: 96086-58-7
4-Chlorobenzyl (3S)-3-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline-2-carbodithioate

Guidance literature:: Multi-step reaction with 3 steps

1: 82.9 percent / methanol / Ambient temperature

2: 76 percent / NaBH₄ / ethanol; H₂O / 1.) room temp., 2 h; 2.) reflux, 3 h

3: 1.) Et₃N / 1.) MeOH, H₂O, room temp., 30 min

With sodium tetrahydroborate; triethylamine; In methanol; ethanol; water;
DOI:10.1248/cpb.35.3262

Reference yield:

: 83159-19-7
methyl (S)-(-)-2,3,4,9-tetrahydro-1H-pyrido<3,4-b>indole-3-carboxylate hydrochloride

: 96086-58-7
4-Chlorobenzyl (3S)-3-hydroxymethyl-1,2,3,4-tetrahydro-β-carboline-2-carbodithioate

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / NaBH₄ / ethanol; H₂O / 1.) room temp., 2 h; 2.) reflux, 3 h

2: 1.) Et₃N / 1.) MeOH, H₂O, room temp., 30 min

With sodium tetrahydroborate; triethylamine; In ethanol; water;
DOI:10.1248/cpb.35.3262